{"id":15967,"date":"2021-10-21T00:48:56","date_gmt":"2021-10-21T00:48:56","guid":{"rendered":"https:\/\/www.cheeridea.mytw.org\/bmi\/%e9%bb%83%e5%ae%a3%e8%aa%a0-hsuan-cheng-huang\/"},"modified":"2026-08-03T16:25:37","modified_gmt":"2026-08-03T08:25:37","slug":"hsuan-cheng-huang","status":"publish","type":"post","link":"https:\/\/bmi.nycu.edu.tw\/en\/hsuan-cheng-huang\/","title":{"rendered":"Hsuan-Cheng Huang"},"content":{"rendered":"\n\n\n\n\n\n\n\n
\n

Personal Profile<\/h2>\n<\/th>\n<\/tr>\n

\"Professor<\/td>\nHsuan-Cheng Huang<\/strong>
\nProfessor, Dept. of Computer Science and Information Engineering, NTU
\nPhD of Physics, National Taiwan University, Taiwan
\nOffice:
\nPhone:
\nEmail: hsuancheng@ntu.edu.tw
\nPersonal website: http:\/\/hchuang.info\/<\/a>
\nORCiD: 0000-0002-3386-0934<\/a>\n<\/td>\n<\/tr>\n
\n

Research Interests<\/h2>\n<\/th>\n<\/tr>\n

\n
    \n
  • Bioinformatics<\/li>\n
  • Computational Biology<\/li>\n
  • Systems Biology<\/li>\n
  • Biomedical Data Science<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n

Publications<\/h2>\n<\/th>\n<\/tr>\n

\n

Journal Papers<\/strong><\/h3>\n

2026<\/strong><\/p>\n

    \n
  • Huang CH<\/strong>, Oyang YJ, Huang HC, Juan HF. scDock: Streamlining drug discovery targeting cell-cell communication via scRNA-seq analysis and molecular docking. Bioinformatics, 42, btag103 (2026).<\/li>\n
  • Yang CC, Lin CY, Yuan HY, Huang HC<\/strong>, Juan HF. Mass spectrometry-based human spatial omics: fundamentals, innovations, and applications. J. Biomed. Sci., 33, 16 (2026). (IF: 12.1)<\/li>\n
  • Lee SC, Yu KH, Huang HC<\/strong>, Juan HF. Reactive oxygen species driven immune inflammation in systemic sclerosis: mechanisms and emerging therapeutics. Drug Discovery Today, 31, 104620 (2026).<\/li>\n<\/ul>\n

    2025<\/strong><\/p>\n

      \n
    • Tseng TY, Hsieh CH, Huang HC<\/strong>, Wu YC, Hsu C, Hsu CL, Ou DL, Juan HF. Transcriptional dynamics of CD8+ T-cell exhaustion in immune checkpoint inhibitor resistance at single-cell resolution. Mol. Cancer, 24, 306 (2025). (IF: 33.9)<\/li>\n
    • Yu PC, Kao YC, Chang HY, Huang CH<\/strong>, Hsu WM, Huang HC, Juan HF. Quantitative proteomics unveils the synergistic effects of combination drugs on cytoskeleton composition and autophagy-mediated cell death in neuroblastoma. J. Proteome. Res., 24, 3578\u22123596 (2025).<\/li>\n
    • Shih JC, Chen PY, Kuo CH, Hsieh CH, Chang HY, Lee HC, Huang CH, Hsu CH, Hsu WM, Huang HC<\/strong>, Juan HF. DHODH blockade induces ferroptosis in neuroblastoma by modulating the mevalonate pathway. Mol. Cell. Proteomics, 24, 101014 (2025).<\/li>\n
    • Tseng TY, Hsieh CH, Liu JY, Huang HC<\/strong>, Juan HF. Single-cell and multi-omics integration reveals cholesterol biosynthesis as a synergistic target with HER2 in aggressive breast cancer. Comput. Struct. Biotechnol. J., 27, 1719-1731 (2025).<\/li>\n
    • Hsieh CH, Chen YX, Tseng TY, Li A, Huang HC<\/strong>, Juan HF. Transcriptionally distinct malignant neuroblastoma populations show selective response to adavosertib treatment. Neurotherapeutics, 22, e00575 (2025).<\/li>\n
    • Su YY, Huang HC<\/strong>, Lin YT, Chuang YF, Sheu SY, Lin CC. HEDDI-Net: heterogeneous network embedding for drug-disease association prediction and drug repurposing, with application to Alzheimer’s disease. J. Transl. Med., 23, 57 (2025). (IF: 7.5)<\/li>\n<\/ul>\n

      2024<\/strong><\/p>\n

        \n
      • Sun YY, Hsieh CY, Wen JH, Tseng TY, Huang JH, Oyang YJ, Huang HC<\/strong>, Juan HF. scDrug+: predicting drug-responses using single-cell transcriptomics and molecular structure. Biomed. Pharmacother. 177, 117070 (2024). (IF: 7.5)<\/li>\n
      • Lee SC, Huang CH, Oyang YJ, Huang HC<\/strong>, Juan HF. Macrophages as determinants and regulators of systemic sclerosis-related interstitial lung disease. J. Transl. Med. 22, 600 (2024). (IF: 7.5)<\/li>\n
      • Wang WH, Kao YC, Hsieh CH, Tsai SY, Cheung CHY, Huang HC<\/strong>, Juan HF. Multiomics reveals induction of neuroblastoma SK-N-BE(2)C cell death by mitochondrial division inhibitor 1 through multiple effects. J. Proteome Res., 23, 301-315 (2024).<\/li>\n<\/ul>\n

        2023<\/strong><\/p>\n

          \n
        • Hsieh CH, Huang CT, Cheng YS, Hsu CH, Hsu WM, Chung YH, Liu YL, Yang TS, Chien CY, Lee YH, Huang HC<\/strong>, Juan HF. Homoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma. Biomed. Pharmacother. 166, 115429 (2023). (IF: 7.5)<\/li>\n
        • Ho WL, Huang HC<\/strong>, Huang JR. IFF: Identifying key residues in intrinsically disordered regions of proteins using machine learning. Protein Sci. 32, e4739 (2023).<\/li>\n
        • Su YY, Liu YL, Huang HC<\/strong>, Lin CC. Ensemble learning model for identifying the hallmark genes of NF\u03baB\/TNF signaling pathway in cancers. J. Transl. Med. 21, 485 (2023).<\/li>\n
        • Kao YC, Chang YW, Lai CP, Chang NW, Huang CH, Chen CS, Huang HC<\/strong>, Juan HF. Ectopic ATP synthase stimulates the secretion of extracellular vesicles in cancer cells. Commun. Biol. 6, 642 (2023).<\/li>\n
        • Chang YW, Tony Yang T, Chen MC, Liaw YG, Yin CF, Lin-Yan XQ, Huang TY, Hou JT, Hung YH, Hsu CL, Huang HC<\/strong>, Juan HF. Spatial and temporal dynamics of ATP synthase from mitochondria toward the cell surface. Commun. Biol. 6, 427 (2023).<\/li>\n
        • Tu YH, Juan HF, Huang HC<\/strong>. Context-dependent gene regulatory network reveals regulation dynamics and cell trajectories using unspliced transcripts. Brief. Bioinform., 24, bbac633 (2023). (IF: 7.7)<\/li>\n
        • Juan HF, Huang HC<\/strong>. Quantitative analysis of high\u2010throughput biological data. WIREs Comput. Mol. Sci., 13, e1658 (2023).<\/li>\n
        • Chen CC, Huang YW, Huang HC<\/strong>, Lo WC, Lyu PC. SeqCP: A sequence-based algorithm for searching circularly permuted proteins. Comput. Struct. Biotechnol. J., 21, 185-201 (2023).<\/li>\n
        • Hsieh CY, Wen JH, Lin SM, Tseng TY, Huang JH, Huang HC<\/strong>, Juan HF. scDrug: From single-cell RNA-seq to drug response prediction. Comput. Struct. Biotechnol. J., 21, 150-157 (2023).<\/li>\n
        • Chen KP, Hsu CL, Oyang YJ, Huang HC<\/strong>, Juan HF. BIC: a database for the transcriptional landscape of bacteria in cancer. Nucleic Acids Res., 51, D1205-D1211 (2023).<\/li>\n<\/ul>\n

          2022<\/strong><\/p>\n

            \n
          • Zhou TA, Hsu HP, Tu YH, Cheng HK, Lin CY, Chen NJ, Tsai JW, Robey EA, Huang HC<\/strong>, Hsu CL, Dzhagalov IL. Thymic macrophages consist of two populations with distinct localization and origin. eLife, 11, e75148 (2022).<\/li>\n
          • Hsu CL, Yin CF, Chang YW, Fan YC, Lin SH, Wu YC, Huang HC<\/strong>, Juan HF. LncRNA SNHG1 regulates neuroblastoma cell fate via interactions with HDAC1\/2. Cell Death Dis., 13, 809 (2022). (IF: 9.6)<\/li>\n
          • Li A, Chen JY, Hsu CL, Oyang YJ, Huang HC<\/strong>, Juan HF. A single-cell network-based drug repositioning strategy for post-COVID-19 pulmonary fibrosis. Pharmaceutics, 14, 971 (2022).<\/li>\n
          • Chang YW, Wang CC, Yin CF, Wu CH, Huang HC<\/strong>, Juan HF. Quantitative phosphoproteomics reveals ectopic ATP synthase on mesenchymal stem cells to promote tumor progression via ERK\/c-Fos pathway activation. Mol. Cell. Proteomics., 21, 100237 (2022).<\/li>\n
          • Yu WH, Hsu CL, Lin CC, Oyang YJ, Juan HF, Huang HC<\/strong>. Stratification of lncRNA modulation networks in breast cancer. BMC Medical Genomics, 14(Suppl 3), 300 (2022).<\/li>\n
          • Yin CF, Chang YW, Huang HC<\/strong>, Juan HF. Targeting protein interaction networks in mitochondria dynamics for cancer therapy. Drug Discovery Today, 27, 1077-1087 (2022). (IF: 7.5)<\/li>\n
          • Ko KY, Chen CY, Juan HF, Huang HC<\/strong>. Phylotranscriptomic patterns of network stochasticity and pathway dynamics during embryogenesis. Bioinformatics, 38, 763\u2013769 (2022). (IF: 7.1)<\/li>\n
          • Chang CS, Yu WH, Su CC, Ruan JW, Lin CM, Huang CT, Tsai YT, Lin IJ, Lai CY, Chuang TH, Lin WJ, Tan TH, Huang HC<\/strong>, Juan HF, Kao CY. Single-cell RNA sequencing uncovers the individual alteration of intestinal mucosal immunocytes in Dusp6 knockout mice. iScience, 25, 103738 (2022).<\/li>\n
          • Yu PC, Huang CH<\/strong>, Kuo CJ, Liang PH, Wang LH, Pan MY, Chang SY, Chao TL, Ieong SM, Fang JT, Huang HC, Juan HF. Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple Targets. Pharmaceutics, 14, 176 (2022).<\/li>\n
          • Hsieh CH, Yeh HN, Huang CT, Wang WH, Hsu WM, Huang HC<\/strong>, Juan HF. BI-2536 Promotes Neuroblastoma Cell Death via Minichromosome Maintenance Complex Components 2 and 10. Pharmaceuticals, 15, 37 (2022).<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

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