{"id":15987,"date":"2021-11-12T07:47:33","date_gmt":"2021-11-12T07:47:33","guid":{"rendered":"https:\/\/www.cheeridea.mytw.org\/bmi\/%e9%bb%83%e5%bd%a5%e8%8f%af-yen-hua-huang\/"},"modified":"2025-05-09T16:57:50","modified_gmt":"2025-05-09T08:57:50","slug":"yen-hua-huang","status":"publish","type":"post","link":"https:\/\/bmi.nycu.edu.tw\/en\/yen-hua-huang\/","title":{"rendered":"Yen-Hua Huang"},"content":{"rendered":"\n\n\n
\n

Personal Profile<\/strong><\/h3>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n
\"\"<\/td>\nYen-Hua Huang<\/strong>
\nAssociate Professor, Institute of Biomedical Informatics
\nPhD of Bioinformatics, The Wellcome Trust Sanger Institute and
\nUniversity of Cambridge, UK
\nField of Interest: Statistical learning of regulatory patterns in eukaryotic
\ngenomes. Integrated analysis and interpretation of high-throughput
\nexperimental data with biological networks. Integrated analysis and
\ninterpretation of next-generation sequencing results.
\nOffice: R309, 3F, SoRen Building
\nPhone: 886-2-28267982
\nEmail: yhhuang@nycu.edu.tw<\/td>\n<\/tr>\n
\n

Research Interests<\/strong><\/h3>\n<\/td>\n<\/tr>\n

\n
    \n
  • \u65b0\u4e16\u4ee3\u5b9a\u5e8f\u6578\u64da\u5206\u6790\u8207\u6574\u5408\u89e3\u8b80 (NGS data analysis and integrated interpretation (e.g. integration with heterogeneous data sources))<\/li>\n
  • \u65b0\u57fa\u56e0\u9ad4\u8a3b\u89e3\u53ca\u6bd4\u8f03\u57fa\u56e0\u9ad4\u5b78 (Annotation of new genomes and comparative genomics based data mining)<\/li>\n
  • \u4eba\u985e\u57fa\u56e0\u8868\u73fe\u53ca\u5176\u8abf\u63a7\u7db2\u8def\u5206\u6790 (Human gene expression profile analysis and regulatory circuit reconstruction)<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
\n

Publications<\/strong><\/h3>\n<\/td>\n<\/tr>\n

\n
    \n
  • Journal Papers<\/strong>\n
      \n
    • Chen, C.L., Tsai, Y.S.,\u00a0Huang, Y.H.<\/strong>, Liang, Y.J., Sun, Y.Y., Su, C.W., Chau, G.Y., Yeh, Y.C., Chang, Y.S., Hu, J.T. et al. (2018) Lymphoid Enhancer Factor 1 Contributes to Hepatocellular Carcinoma Progression Through Transcriptional Regulation of Epithelial-Mesenchymal Transition Regulators and Stemness Genes. Hepatol Commun, 2, 1392-1407.<\/li>\n
    • Huang, Y.H.<\/strong>, Chou, S.H., Liang, S.W., Ni, C.E., Lin, Y.T., Huang, Y.W. and Yang, T.C. (2018) Emergence of an XDR and carbapenemase-producing hypervirulent Klebsiella pneumoniae strain in Taiwan. J Antimicrob Chemother.<\/li>\n
    • Chang, C.W., Liu, C.Y., Lee, H.C.,\u00a0Huang, Y.H.<\/strong>, Lee, L.H., Chiang Chiau, J.S., Wang, T.E., Chu, C.H., Shih, S.C., *Tsai, T.H. and *Chen, Y.J. (2018) Lactobacillus casei Variety rhamnosus Probiotic Preventively Attenuates 5-Fluorouracil\/Oxaliplatin-Induced Intestinal Injury in a Syngeneic Colorectal Cancer Model. Front. Microbiol., doi:10.3389\/fmicb.2018.00983<\/li>\n
    • Hu, Y.F., Chang, Y.T., Lin, Y.J., Chang, S.L., Lo, L.W.,\u00a0Huang, Y.H.<\/strong>, Liu, T.T., Chen, C.H., Tuan, T.C., Chao, T.F. et al. (2017) The roles of alcohol dehydrogenase in patients with atrial fibrillation. Pacing Clin Electrophysiol. doi: 10.1111\/pace.13208.<\/li>\n
    • Tsai, P.C.,\u00a0Huang, Y.H.<\/strong>, Guo, Y.C., Wu, H.T., Lin, K.P., Tsai, Y.S., Liao, Y.C., Liu, Y.T., Liu, T.T., Kao, L.S., et al. (2014). A novel TFG mutation causes Charcot-Marie-Tooth disease type 2 and impairs TFG function. Neurology 83, 903-912. (HYH and TPC contributed equally.)<\/li>\n
    • Huang, Y.-H.<\/strong>, Wu, H.-Y., Wu, K.-M., Liu, T.-T., Liou, R.-F., Tsai, S.-F., Shiao, M.-S., Ho, L.-T., Tzean, S.-S. and Yang, U.-C. (2013) Generation and analysis of the expressed sequence tags from the mycelium of Ganoderma lucidum. PLoS One, 8, e61127<\/li>\n
    • Soong, B.-W.,\u00a0Huang, Y.-H.<\/strong>, Tsai, P.-C., Huang, C.-C., Pan, H.-C., Lu, Y.-C., Chien, H.-J., Liu, T.-T., Chang, M.-H., Lin, K.-P. et al. (2013) Exome Sequencing Identifies GNB4 Mutations as a Cause of Dominant Intermediate Charcot-Marie-Tooth Disease. Am J Hum Genet, 92, 422-430. (HYH and SBW contributed equally.) (Selected for the press release by this journal)<\/li>\n
    • Lee, Y.-C., Durr, A., Majczenko, K.,\u00a0Huang, Y.-H.<\/strong>, Liu, Y.-C., Lien, C.-C., Tsai, P.-C., Ichikawa, Y., Goto, J., Monin, M.L. et al. (2012) Mutations in KCND3 cause spinocerebellar ataxia type 22. Ann Neurol, 72, 859-869. (Reviewed and commented by Nature Review Neurology)<\/li>\n
    • Hsu, C.-L.,\u00a0Huang, Y.-H.<\/strong>, Hsu, C.-T. and Yang, U.-C. (2011) Prioritizing disease candidate genes by a gene interconnectedness-based approach. BMC Genomics, 12 Suppl 3, S25.<\/li>\n
    • Wang, Y.-T.,\u00a0Huang, Y.-H.<\/strong>, Chen, Y.-C., Hsu, C.-L. and Yang, U.-C. (2010) PINT: Pathways INtegration Tool. Nucleic Acids Res, 38 Suppl, W124-131. (HYH and WYT contributed equally.) (One of the featured articles of Nucleic Acids Research (NAR), highlighting the best 5% papers published in 2010 in this journal.)<\/li>\n<\/ul>\n<\/li>\n
    • Conference Posters<\/strong>\n
        \n
      • Ho, T.-C., Chiu, J.-Y., Lin, H.-J.,\u00a0Huang, Y.-H.<\/strong>, Yang, U.-C. Automating the virtualization of Ensembl genome browser and database server. Joint Annual Conference of Biomedical Science, Taiwan, ROC. Apr. 2014.<\/li>\n
      • Lin, H.-J., Chiu, H.-C.,\u00a0Huang, Y.-H.<\/strong>, Yang, U.-C. Next Generation Sequencing (NGS) data analysis in cloud environment. Joint Annual Conference of Biomedical Science, Taiwan, ROC. Apr. 2014.<\/li>\n
      • Pan, J.-P., Chiu, J.-Y.,\u00a0Huang, Y.-H.<\/strong>, Yang, U.-C. The copy number of a lipopolysaccharide biosynthesis-related protein domain appears to correlate with the virulence among Acinetobacter baumannii isolates. Joint Annual Conference of Biomedical Science, Taiwan, ROC. Apr. 2014.<\/li>\n
      • Chiu, H.-C., Yang, U.-C.,\u00a0Huang, Y.-H.<\/strong>\u00a0Using RNA-sequencing data of a non-familial cancer to screen causative single-nucleotide variants (SNVs). Joint Annual Conference of Biomedical Science, Taiwan, ROC. Apr. 2013.<\/li>\n
      • Wang, S.-G., Chiu, J.-Y.,\u00a0Huang, Y.-H.<\/strong>, Yang, U.-C. Designing primers for polymerase chain reactions based on next generation sequencing data to identify virulence factors of pathogens. Joint Annual Conference of Biomedical Science, Taiwan, ROC. Apr. 2013.<\/li>\n
      • Sun, T.-Y.,\u00a0Huang, Y.-H.<\/strong>, Chang, C.-C, Yang, U.-C.. A quick method to detect splicing pattern changes by using RNA Sequencing. Joint Annual Conference of Biomedical Science, Taiwan, ROC. Apr. 2013.<\/li>\n
      • Tseng, Y.-C.,\u00a0Huang, Y.-H.<\/strong>, Yang, U.-C. Annotation of the ligand specificity of glycosylation enzymes in Ganoderma lucidum. Bioinformatics in Taiwan (BIT), National Yang-Ming University, Taiwan, ROC. Oct. 2012.<\/li>\n
      • Chou, K.-M., Yang, U.-C.,\u00a0Huang, Y.-H.<\/strong>\u00a0Using exome sequencing data from familial cancers to find cancer-causing genetic variants. Bioinformatics in Taiwan (BIT), National Yang-Ming University, Taiwan, ROC. Oct. 2012.<\/li>\n
      • Chiu, H.-C., Yang, U.-C.,\u00a0Huang, Y.-H.<\/strong>\u00a0Screening causative single-nucleotide variants (SNVs) from RNA-sequencing data of a non-familial cancer. Bioinformatics in Taiwan (BIT), National Yang-Ming University, Taiwan, ROC. Oct. 2012.<\/li>\n
      • Wang, S.-G., Chiu, J.-Y.,\u00a0Huang, Y.-H.<\/strong>, Yang, U.-C. The identification ofs virulence factors of pathogenic infection by using next generation sequence data. Bioinformatics in Taiwan (BIT), National Yang-Ming University, Taiwan, ROC. Oct. 2012.<\/li>\n
      • Huang, Y.-H.<\/strong>, Hsu, J.-T., Chen, C.-Y., Yang, U.-C. and Tien, H.-F. FusionDetector: a flexible pipeline for finding aberrant fusion genes using RNA-seq data. Cold Spring Harbor Asia 2011 bioinformatics of human and animal genomics. Suzhou, China, Nov. 2011.<\/li>\n
      • Chiu, H.-C., Chou, K.-M.,\u00a0Huang, Y.-H.<\/strong>, Yang, U.-C. A family-based filtering strategy to prioritize causative single nucleotide variants. Bioinformatics in Taiwan (BIT), National Yang-Ming University, Taiwan, ROC. Sept. 2011.<\/li>\n
      • Tseng, Y.-C.,\u00a0Huang, Y.-H.<\/strong>, Yang, U.-C. Analysis RNA-seq from original data to candidate cancer genes by Galaxy. Bioinformatics in Taiwan (BIT), National Yang-Ming University, Taiwan, ROC. Sept. 2011.<\/li>\n
      • Hsu, J.-T., Chen, C.-Y., Yang, U.-C., Tien, H.-F.,\u00a0Huang, Y.-H.<\/strong>\u00a0Finding and annotating cancer-associated fusion genes from next-generation sequencing results. Joint Annual Conference of Biomedical Science, Taiwan, ROC. Apr. 2010.<\/li>\n
      • Huang, Y.-H.<\/strong>, Down, T., Hubbard, T.J.P., A real-life assessment of comparative-genomics-based noncoding RNA finding algorithms. Joint Annual Conference of Biomedical Science, Taiwan, ROC. Apr. 2008.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

        Personal Profile Yen-Hua Huang Associate Professor, Institute of Biomedical Informatics PhD of Bioinformatics, The Wellcome Trust Sanger Institute and University of Cambridge, UK Field of Interest: Statistical learning of regulatory patterns in eukaryotic genomes. Integrated analysis and interpretation of high-throughput experimental data with biological networks. Integrated analysis and interpretation of next-generation sequencing results. Office: R309,..<\/p>\n","protected":false},"author":1,"featured_media":15710,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[],"class_list":["post-15987","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category--en"],"yoast_head":"\nYen-Hua Huang - \u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78 \u751f\u7269\u91ab\u5b78\u8cc7\u8a0a\u7814\u7a76\u6240<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/bmi.nycu.edu.tw\/en\/yen-hua-huang\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Yen-Hua Huang - \u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78 \u751f\u7269\u91ab\u5b78\u8cc7\u8a0a\u7814\u7a76\u6240\" \/>\n<meta property=\"og:description\" content=\"Personal Profile Yen-Hua Huang Associate Professor, Institute of Biomedical Informatics PhD of Bioinformatics, The Wellcome Trust Sanger Institute and University of Cambridge, UK Field of Interest: Statistical learning of regulatory patterns in eukaryotic genomes. Integrated analysis and interpretation of high-throughput experimental data with biological networks. Integrated analysis and interpretation of next-generation sequencing results. 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