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Microbiome Project, HMP)\u5c31\u9ad8\u905417\u5104\u7f8e\u5143\u7684\u7d93\u8cbb\uff0cHMP\u8a08\u756b\u7b2c\u4e00\u968e\u6bb5\u4ee5\u900f\u904e\u5b9a\u5e8f\u5206\u6790\u5efa\u7acb\u4eba\u9ad4\u5fae\u751f\u7269\u7d44\u7684\u5e8f\u5217\u8cc7\u6599\u5eab\u70ba\u4e3b\u8981\u91cd\u9ede\uff0c\u7b2c\u4e8c\u968e\u6bb5\u5247\u5df2\u7d50\u5408\u5148\u524d\u5b9a\u5e8f\u7684\u767c\u73fe\u53ca\u5404\u7a2e\u7814\u7a76\u5be6\u9a57\uff0c\u671d\u5411\u89e3\u6790\u5fae\u751f\u7269\u7d44\u8207\u4eba\u9ad4\u75be\u75c5\u767c\u751f\u4e4b\u95dc\u806f\u6027\u53ca\u6a5f\u5236\u3002\u6b50\u76df\u4eba\u9ad4\u8178\u9053\u7e3d\u9ad4\u57fa\u56e0\u9ad4\u5b78\u7814\u7a76\u8a08\u756b(Metagenomics of the Human Intestinal Tract, MetaHIT)\u7d50\u5408\u6b50\u6d328\u570b\u517115\u500b\u7814\u7a76\u6a5f\u69cb\u5171\u540c\u6295\u5165\u5fae\u83cc\u76f8\u95dc\u7814\u7a76\uff0c\u7814\u7a76\u91cd\u9ede\u9664\u5efa\u7acb\u4eba\u9ad4\u8178\u9053\u5fae\u83cc\u53c3\u8003\u8cc7\u6599\u5eab\u5916\uff0c\u4ea6\u5305\u62ec\u5340\u8fa8\u4e0d\u540c\u65cf\u7fa4\u6240\u5e36\u6709\u7684\u83cc\u76f8\u5dee\u7570\u3001\u53ca\u767c\u5c55\u61c9\u7528\u65bc\u5fae\u83cc\u5206\u6790\u7684\u751f\u91ab\u5de5\u5177\u3002\u4e2d\u570b\u4ea6\u81ea2017\u5e74\u5e95\u7531\u4e2d\u570b\u79d1\u5b78\u9662\u5fae\u751f\u7269\u7814\u7a76\u6240\u8207\u4e2d\u79d1\u9662\u4e0a\u6d77\u751f\u547d\u79d1\u5b78\u7814\u7a76\u9662\u7b49\u517114\u500b\u7814\u7a76\u55ae\u4f4d\uff0c\u5c55\u958b\u201c\u4eba\u9ad4\u8207\u74b0\u5883\u5065\u5eb7\u7684\u5fae\u751f\u7269\u7d44\u5171\u6027\u6280\u8853\u7814\u7a76\u201d\u66a8\u201c\u4e2d\u570b\u79d1\u5b78\u9662\u5fae\u751f\u7269\u7d44\u8a08\u756b\u201d\uff0c\u4ee5\u570b\u5bb6\u578b\u8a08\u756b\u6295\u5165\u7814\u7a76\u4eba\u9ad4\u8178\u9053\u5fae\u751f\u7269\u7d44\u3001\u5efa\u7acb\u5fae\u751f\u7269\u7d44\u529f\u80fd\u89e3\u6790\u6280\u8853\u8207\u8a08\u7b97\u65b9\u6cd5\u5b78\uff0c\u4ee5\u53ca\u5efa\u7acb\u4e2d\u570b\u5fae\u751f\u7269\u7d44\u8cc7\u6599\u5eab\u8207\u8cc7\u6e90\u5eab\u3002\u53f0\u7063\u4ea6\u6709\u9451\u6b64\u4e00\u91cd\u8981\u7814\u7a76\u8b70\u984c\uff0c\u79d1\u6280\u90e8\u7279\u5225\u81ea2018\u5e74\u958b\u59cb\u5fb5\u6c42\u300c\u4eba\u9ad4\u5fae\u751f\u7269\u76f8\u5c08\u6848\u7814\u7a76\u8a08\u756b\u300d\u5148\u5c0e\u8a08\u756b\uff0c\u4e26\u8003\u91cf\u570b\u969b\u767c\u5c55\u7684\u8da8\u5411\u53ca\u570b\u5167\u7522\u5b78\u7684\u91cf\u80fd\uff0c\u8a02\u51fa\u5148\u671f\u7814\u7a76\u76ee\u6a19\u805a\u7126\u65bc\uff1a(1)\u958b\u767c\u4ee5\u5fae\u751f\u7269\u76f8\u70ba\u75be\u75c5\u8a3a\u65b7\u8207\u9810\u9632\u4e4b\u751f\u7269\u6a19\u8a18\u6216\u6280\u8853\uff1b(2)\u7814\u767c\u8abf\u6574\u5fae\u751f\u7269\u76f8\u4e4b\u85e5\u7269\uff08\u5305\u542b\u4e2d\u8349\u85e5\u8207\u8001\u85e5\u65b0\u7528\u7b49\uff09\u3001\u5fae\u751f\u7269\u7fa4\u6216\u5176\u4ed6\u65b9\u6cd5\uff1b(3)\u63a2\u8a0e\u5fae\u751f\u7269\u76f8\u5c0d\u73fe\u6709\u85e5\u7269\u6cbb\u7642\uff08\u5982\u5316\u7642\u3001\u514d\u75ab\u6cbb\u7642\u7b49\uff09\u6548\u7528\u4e4b\u5f71\u97ff\u7b49\u3002<br>\u7d9c\u4e0a\u6240\u8ff0\u53ef\u898b\u5fae\u83cc\u7814\u7a76\u65e9\u5df2\u53d7\u5230\u570b\u969b\u9593\u4e4b\u91cd\u8996\uff0c\u7136\u800c\uff0c\u570b\u5167\u5728\u4eba\u9ad4\u5fae\u83cc\u76f8\u95dc\u7814\u7a76\u4eba\u624d\u4e4b\u57f9\u80b2\u65b9\u9762\uff0c\u4ecd\u6b20\u7f3a\u4e3b\u8cac\u7684\u76f8\u95dc\u5c08\u9580\u7cfb\u6240\uff0c\u5fae\u83cc\u7814\u7a76\u9664\u9700\u77ad\u89e3\u50b3\u7d71\u5fae\u751f\u7269\u7814\u7a76\u65b9\u6cd5\uff0c\u5982\u986f\u5fae\u93e1\u5fae\u5f62\u614b\u89c0\u5bdf\u3001\u9078\u64c7\u6027\u57f9\u990a\u57fa\u8a08\u6578\u3001\u7d14\u83cc\u7a2e\u5206\u96e2\u548c\u751f\u7406\u751f\u5316\u9452\u5b9a\u7b49\uff0c\u5c0d\u5fae\u751f\u7269\u591a\u6a23\u6027\u4e4b\u5b9a\u6027\u5b9a\u91cf\u53ca\u5fae\u83cc\u5de8\u91cf\u8cc7\u6599\u8655\u7406\u7b49\u751f\u91ab\u7814\u7a76\u65b9\u6cd5\uff0c\u66f4\u662f\u7576\u524d\u570b\u969b\u9593\u91cd\u8981\u7684\u65b0\u767c\u5c55\u9818\u57df\uff0c\u8fd1\u5e74\u96a8\u8457\u57fa\u56e0\u5b9a\u5e8f\u6280\u8853\u7684\u9032\u5c55\uff0c\u5404\u570b\u7814\u7a76\u7684\u4e3b\u8981\u6230\u5834\u5747\u8f49\u79fb\u81f3\u5229\u7528\u7528\u57fa\u56e0\u5e8f\u5217\u4f86\u5206\u6790\u5fae\u751f\u7269\u9593\u7684\u89aa\u7de3\u6216\u9032\u5316\u95dc\u806f\u5206\u6790\uff0c\u9032\u800c\u5c55\u958b\u5fae\u751f\u7269\u7684\u7cfb\u7d71\u9032\u5316\u3001\u5206\u985e\u53ca\u591a\u6a23\u6027\u7b49\u5b9a\u6027\u5b9a\u91cf\u4e4b\u7814\u7a76\uff0c\u4e43\u81f3\u5c0e\u5165\u4ee5\u5927\u6578\u64da\u8207\u4eba\u5de5\u667a\u6167\u65b9\u6cd5\u5206\u6790\u5fae\u751f\u7269\u76f8\u8cc7\u6599\u5eab\u4e4b\u5de8\u91cf\u6578\u64da\uff0c\u4ee5\u9032\u4e00\u6b65\u5c0b\u6c42\u63d0\u4f9b\u8a3a\u65b7\u6216\u9810\u6e2c\u75be\u75c5\u767c\u751f\u7684\u53ef\u80fd\u6a21\u5f0f\uff0c\u5747\u662f\u5fae\u83cc\u7814\u7a76\u5f88\u6709\u767c\u5c55\u6f5b\u529b\u7684\u65b9\u5411\u3002<\/p>\n\n\n\n<p style=\"font-size:18px\"><strong>\u8a2d\u7acb\u5b97\u65e8<\/strong><\/p>\n\n\n\n<p>\u6253\u9020\u672a\u4f86\u4e16\u4ee3\u8de8\u9818\u57df\u5fae\u83cc\u7814\u7a76\u7684\u512a\u8cea\u4eba\u624d\u8207\u5718\u968a\u3002<\/p>\n\n\n\n<p style=\"font-size:18px\"><strong>\u8a2d\u7acb\u76ee\u7684<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>\u57f9\u990a\u5fae\u83cc\u7814\u7a76\u6240\u9700\u7684\u8de8\u9818\u57df\u7814\u7a76\u4eba\u624d\u3002<\/li><li>\u5f62\u6210\u8de8\u57fa\u790e\u3001\u81e8\u5e8a\u8207\u751f\u8cc7\u7684\u5fae\u83cc\u7814\u7a76\u5718\u968a\u3002<\/li><li>\u6a4b\u63a5\u5fae\u83cc\u76f8\u95dc\u7522\u5b78\u7814\u7a76\u5408\u4f5c\u3002<\/li><\/ol>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\"><\/div>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p style=\"font-size:22px\"><strong>\u5b78\u7a0b\u7ba1\u7406\u8fa6\u6cd5<\/strong><\/p>\n\n\n\n<p style=\"font-size:18px\"><strong>\u6cd5\u6e90\u4f9d\u64da<\/strong><\/p>\n\n\n\n<p>\u7ba1\u7406\u8fa6\u6cd5\u4f9d\u64da\u300c\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78\u5b78\u7a0b\u8a2d\u7f6e\u8fa6\u6cd5\u300d\u8a02\u5b9a\u3002<\/p>\n\n\n\n<p style=\"font-size:18px\"><strong>\u7d44\u7e54\u67b6\u69cb<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>\u672c\u5b78\u7a0b\u7f6e\u8ca0\u8cac\u4eba\u4e00\u4eba\uff0c\u7d71\u7c4c\u53ca\u8fa6\u7406\u5404\u9805\u5b78\u7a0b\u76f8\u95dc\u4e8b\u7269\u3002\u7531\u672c\u300c\u5b78\u7a0b\u6559\u5e2b\u6703\u8b70\u300d\u63a8\u85a6\u526f\u6559\u6388\uff08\u542b\uff09\u4ee5\u4e0a\u6559\u5e2b\uff0c\u7531\u6821\u9577\u9074\u8058\u517c\u4efb\uff0c\u4efb\u671f\u4e8c\u5e74\uff0c\u4e26\u5f97\u9023\u4efb\u4e8c\u6b21\u3002\u9023\u4efb\u6642\u9700\u7d93\u300c\u5b78\u7a0b\u6559\u5e2b\u6703\u8b70\u300d\u540c\u610f\u5f8c\uff0c\u85a6\u8acb\u6821\u9577\u8058\u4efb\u3002<\/li><li>\u672c\u5b78\u7a0b\u6bcf\u5b78\u671f\u53ec\u958b\u300c\u5b78\u7a0b\u6559\u5e2b\u6703\u8b70\u300d\u4e59\u6b21\uff0c\u8a0e\u8ad6\u8207\u8b70\u6c7a\u5404\u9805\u6559\u5b78\u53ca\u884c\u653f\u4e8b\u7269\uff0c\u4e26\u8996\u9700\u8981\uff0c\u5f97\u8a2d\u7f6e\u76f8\u95dc\u59d4\u54e1\u6703\u3002\u5b78\u7a0b\u6559\u5e2b\u5f97\u8996\u9700\u8981\uff0c\u7d93\u300c\u5b78\u7a0b\u6559\u5e2b\u6703\u8b70\u300d\u540c\u610f\u5f8c\uff0c\u9080\u8acb\u6821\u5167\u3001\u5916\u6559\u5e2b\u53c3\u8207\u672c\u5b78\u7a0b\u3002<\/li><\/ol>\n\n\n\n<p style=\"font-size:18px\"><strong>\u62db\u751f<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\" id=\"block-e4c77469-9354-4da2-a4c5-137825e33e53\"><li>\u672c\u5b78\u7a0b\u62db\u6536\u672c\u6821\u5927\u5b78\u90e8\u8207\u7814\u7a76\u6240\u5b78\u751f\u3002<\/li><li>\u4fee\u7fd2\u672c\u5b78\u7a0b\u4e4b\u5b78\u751f\uff0c\u5747\u9700\u4f9d\u672c\u5b78\u7a0b\u4fee\u696d\u8fa6\u6cd5\u4e4b\u898f\u5b9a\u4fee\u7fd2\u4e4b\u3002<\/li><\/ol>\n\n\n\n<p style=\"font-size:18px\"><strong>\u5176\u4ed6\u76f8\u95dc\u898f\u5b9a<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\" id=\"block-bcc41953-072d-4049-8041-950abfb5ac53\"><li>\u672c\u8fa6\u6cd5\u82e5\u6709\u672a\u76e1\u4e8b\u5b9c\uff0c\u6089\u4f9d\u672c\u6821\u76f8\u95dc\u898f\u5b9a\u8fa6\u7406\u3002<\/li><li>\u672c\u8fa6\u6cd5\u7d93\u672c\u6821\u6559\u52d9\u6703\u8b70\u901a\u904e\u5f8c\u5be6\u65bd\uff0c\u4fee\u6b63\u6642\u4ea6\u540c\u3002<\/li><\/ol>\n\n\n\n<p 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