黃彥華
Yen-Hua Huang

個人簡歷

• 職稱：    副教授, 生物醫學資訊研究所
• 學歷：    英國劍橋大學桑格(The Wellcome Trust Sanger Institute)生物資訊學博士
• 辦公室： 守仁樓三樓 309室
• 電話：    886-2-28267982
• Email：  yhhuang@nycu.edu.tw
• 個人網頁：

研究領域

• 新世代定序數據分析與整合解讀 (NGS data analysis and integrated interpretation (e.g. integration with heterogeneous data sources))
• 新基因體註解及比較基因體學 (Annotation of new genomes and comparative genomics based data mining)
• 人類基因表現及其調控網路分析 (Human gene expression profile analysis and regulatory circuit reconstruction)

研究著作

• Journal Papers
  • Chen, C.L., Tsai, Y.S., Huang, Y.H., Liang, Y.J., Sun, Y.Y., Su, C.W., Chau, G.Y., Yeh, Y.C., Chang, Y.S., Hu, J.T. et al. (2018) Lymphoid Enhancer Factor 1 Contributes to Hepatocellular Carcinoma Progression Through Transcriptional Regulation of Epithelial-Mesenchymal Transition Regulators and Stemness Genes. Hepatol Commun, 2, 1392-1407.
  • Huang, Y.H., Chou, S.H., Liang, S.W., Ni, C.E., Lin, Y.T., Huang, Y.W. and Yang, T.C. (2018) Emergence of an XDR and carbapenemase-producing hypervirulent Klebsiella pneumoniae strain in Taiwan. J Antimicrob Chemother.
  • Chang, C.W., Liu, C.Y., Lee, H.C., Huang, Y.H., Lee, L.H., Chiang Chiau, J.S., Wang, T.E., Chu, C.H., Shih, S.C., *Tsai, T.H. and *Chen, Y.J. (2018) Lactobacillus casei Variety rhamnosus Probiotic Preventively Attenuates 5-Fluorouracil/Oxaliplatin-Induced Intestinal Injury in a Syngeneic Colorectal Cancer Model. Front. Microbiol., doi:10.3389/fmicb.2018.00983
  • Hu, Y.F., Chang, Y.T., Lin, Y.J., Chang, S.L., Lo, L.W., Huang, Y.H., Liu, T.T., Chen, C.H., Tuan, T.C., Chao, T.F. et al. (2017) The roles of alcohol dehydrogenase in patients with atrial fibrillation. Pacing Clin Electrophysiol. doi: 10.1111/pace.13208.
  • Tsai, P.C., Huang, Y.H., Guo, Y.C., Wu, H.T., Lin, K.P., Tsai, Y.S., Liao, Y.C., Liu, Y.T., Liu, T.T., Kao, L.S., et al. (2014). A novel TFG mutation causes Charcot-Marie-Tooth disease type 2 and impairs TFG function. Neurology 83, 903-912. (HYH and TPC contributed equally.)
  • Huang, Y.-H., Wu, H.-Y., Wu, K.-M., Liu, T.-T., Liou, R.-F., Tsai, S.-F., Shiao, M.-S., Ho, L.-T., Tzean, S.-S. and Yang, U.-C. (2013) Generation and analysis of the expressed sequence tags from the mycelium of Ganoderma lucidum. PLoS One, 8, e61127
  • Soong, B.-W., Huang, Y.-H., Tsai, P.-C., Huang, C.-C., Pan, H.-C., Lu, Y.-C., Chien, H.-J., Liu, T.-T., Chang, M.-H., Lin, K.-P. et al. (2013) Exome Sequencing Identifies GNB4 Mutations as a Cause of Dominant Intermediate Charcot-Marie-Tooth Disease. Am J Hum Genet, 92, 422-430. (HYH and SBW contributed equally.) (Selected for the press release by this journal)
  • Lee, Y.-C., Durr, A., Majczenko, K., Huang, Y.-H., Liu, Y.-C., Lien, C.-C., Tsai, P.-C., Ichikawa, Y., Goto, J., Monin, M.L. et al. (2012) Mutations in KCND3 cause spinocerebellar ataxia type 22. Ann Neurol, 72, 859-869. (Reviewed and commented by Nature Review Neurology)
  • Hsu, C.-L., Huang, Y.-H., Hsu, C.-T. and Yang, U.-C. (2011) Prioritizing disease candidate genes by a gene interconnectedness-based approach. BMC Genomics, 12 Suppl 3, S25.
  • Wang, Y.-T., Huang, Y.-H., Chen, Y.-C., Hsu, C.-L. and Yang, U.-C. (2010) PINT: Pathways INtegration Tool. Nucleic Acids Res, 38 Suppl, W124-131. (HYH and WYT contributed equally.) (One of the featured articles of Nucleic Acids Research (NAR), highlighting the best 5% papers published in 2010 in this journal.)
• Conference Posters
  • Ho, T.-C., Chiu, J.-Y., Lin, H.-J., Huang, Y.-H., Yang, U.-C. Automating the virtualization of Ensembl genome browser and database server. Joint Annual Conference of Biomedical Science, Taiwan, ROC. Apr. 2014.
  • Lin, H.-J., Chiu, H.-C., Huang, Y.-H., Yang, U.-C. Next Generation Sequencing (NGS) data analysis in cloud environment. Joint Annual Conference of Biomedical Science, Taiwan, ROC. Apr. 2014.
  • Pan, J.-P., Chiu, J.-Y., Huang, Y.-H., Yang, U.-C. The copy number of a lipopolysaccharide biosynthesis-related protein domain appears to correlate with the virulence among Acinetobacter baumannii isolates. Joint Annual Conference of Biomedical Science, Taiwan, ROC. Apr. 2014.
  • Chiu, H.-C., Yang, U.-C., Huang, Y.-H. Using RNA-sequencing data of a non-familial cancer to screen causative single-nucleotide variants (SNVs). Joint Annual Conference of Biomedical Science, Taiwan, ROC. Apr. 2013.
  • Wang, S.-G., Chiu, J.-Y., Huang, Y.-H., Yang, U.-C. Designing primers for polymerase chain reactions based on next generation sequencing data to identify virulence factors of pathogens. Joint Annual Conference of Biomedical Science, Taiwan, ROC. Apr. 2013.
  • Sun, T.-Y., Huang, Y.-H., Chang, C.-C, Yang, U.-C.. A quick method to detect splicing pattern changes by using RNA Sequencing. Joint Annual Conference of Biomedical Science, Taiwan, ROC. Apr. 2013.
  • Tseng, Y.-C., Huang, Y.-H., Yang, U.-C. Annotation of the ligand specificity of glycosylation enzymes in Ganoderma lucidum. Bioinformatics in Taiwan (BIT), National Yang-Ming University, Taiwan, ROC. Oct. 2012.
  • Chou, K.-M., Yang, U.-C., Huang, Y.-H. Using exome sequencing data from familial cancers to find cancer-causing genetic variants. Bioinformatics in Taiwan (BIT), National Yang-Ming University, Taiwan, ROC. Oct. 2012.
  • Chiu, H.-C., Yang, U.-C., Huang, Y.-H. Screening causative single-nucleotide variants (SNVs) from RNA-sequencing data of a non-familial cancer. Bioinformatics in Taiwan (BIT), National Yang-Ming University, Taiwan, ROC. Oct. 2012.
  • Wang, S.-G., Chiu, J.-Y., Huang, Y.-H., Yang, U.-C. The identification ofs virulence factors of pathogenic infection by using next generation sequence data. Bioinformatics in Taiwan (BIT), National Yang-Ming University, Taiwan, ROC. Oct. 2012.
  • Huang, Y.-H., Hsu, J.-T., Chen, C.-Y., Yang, U.-C. and Tien, H.-F. FusionDetector: a flexible pipeline for finding aberrant fusion genes using RNA-seq data. Cold Spring Harbor Asia 2011 bioinformatics of human and animal genomics. Suzhou, China, Nov. 2011.
  • Chiu, H.-C., Chou, K.-M., Huang, Y.-H., Yang, U.-C. A family-based filtering strategy to prioritize causative single nucleotide variants. Bioinformatics in Taiwan (BIT), National Yang-Ming University, Taiwan, ROC. Sept. 2011.
  • Tseng, Y.-C., Huang, Y.-H., Yang, U.-C. Analysis RNA-seq from original data to candidate cancer genes by Galaxy. Bioinformatics in Taiwan (BIT), National Yang-Ming University, Taiwan, ROC. Sept. 2011.
  • Hsu, J.-T., Chen, C.-Y., Yang, U.-C., Tien, H.-F., Huang, Y.-H. Finding and annotating cancer-associated fusion genes from next-generation sequencing results. Joint Annual Conference of Biomedical Science, Taiwan, ROC. Apr. 2010.
  • Huang, Y.-H., Down, T., Hubbard, T.J.P., A real-life assessment of comparative-genomics-based noncoding RNA finding algorithms. Joint Annual Conference of Biomedical Science, Taiwan, ROC. Apr. 2008.