專任教授

王禹超 (Yu-Chao Wang)

個人簡歷
  • 職稱：    教授, 生物醫學資訊研究所
  • 學歷：    國立清華大學電機工程學系博士
  • 辦公室： 守仁樓三樓 307室
  • 電話：    886-2-28267973
  • Email：  yuchao@nycu.edu.tw
  • 個人網頁：https://yuchao.web.nycu.edu.tw/

研究領域
  • 生醫數據分析與人工智慧之臨床應用 (Biomedical data analysis and AI in healthcare)
  • 轉譯生物資訊 (Translational bioinformatics)
  • 系統生物學 (Systems biology)

研究著作
  • Yeh YC*, Chu PY, Lin SY, Wang SY, Ho HL, Wang YC*, “Comprehensive genomic and transcriptomic analysis of sclerosing pneumocytoma” Modern Pathology, 37(1):100354, 2024.
  • Chang JW, Huang CJ, Huang WK, Wang YC, Hsieh JJ, Chang YY, Huang YL, Wu CL, Wang YH, Chen SJ, Tan KT, Chen CP, Wu CE*, “Genomic and tumour microenvironmental biomarkers of immune checkpoint inhibitor response in advanced Taiwanese melanoma” Clinical & Translational Immunology, 12(8):e1465, 2023.
  • Chen TH, Chen MH, Hung YP, Chiang NJ, Huang KH, Lin YH, Lin RW, Chao Y, Li AF, Yu HY, Huang HE, Yeh YC, Wang YC*, Fang WL*, “Elevated PD-L1 expression and microsatellite instability in elderly patients with gastric cancer” Journal of Immunotherapy, 46(3):111-119, 2023.
  • Sanmarco LM†, Chao CC†, Wang YC†, Kenison JE†, Li Z, Rone JM, Rejano-Gordillo CM, Polonio CM, Gutierrez-Vazquez C, Piester G, Plasencia A, Li L, Giovannoni F, Lee HG, Faust Akl C, Wheeler MA, Mascanfroni I, Jaronen M, Alsuwailm M, Hewson P, Yeste A, Andersen BM, Franks DG, Huang CJ, Ekwudo M, Tjon EC, Rothhammer V, Takenaka M, de Lima KA, Linnerbauer M, Guo L, Covacu R, Queva H, Fonseca-Castro PH, Bladi MA, Cox LM, Hodgetts KJ, Hahn ME, Mildner A, Korzenik J, Hauser R, Snapper SB, Quintana FJ*, “Identification of environmental factors that promote intestinal inflammation” Nature, 611(7937):801-809, 2022. †co-first author
  • Pan CC*, Tseng CE, Kuroda N, Yano M, Yasuda M, Nagashima Y, Yeh YC, Wang YC, Chang YH, Epstein JI, “Molecular characterization of metanephric adenoma, epithelial Wilms tumor and overlap lesions: An integrated whole exome and transcriptome sequencing analysis” Applied Immunohistochemistry & Molecular Morphology, 30(4):257-263, 2022.
  • Yu HY, Li CP, Huang YH, Hsu SJ, Wang YP, Hsieh YC, Fang WL, Huang KH, Li AF, Lee RC, Lee KL, Wu YH, Lai IC, Yang WC, Hung YP, Wang YC, Chen SH, Chen MH*, Chao Y*, “Microsatellite instability, Epstein–Barr virus, and programmed cell death ligand 1 as predictive markers for immunotherapy in gastric cancer”Cancers, 14(1):218, 2022.
  • Lin YY†, Wang YC†, Yeh DW, Hung CY, Yeh YC, Ho HL, Mon HC, Chen MY, Wu YC, Chou TY*, “Gene expression profile in primary tumor is associated with brain-tropism of metastasis from lung adenocarcinoma” International Journal of Molecular Sciences, 22(24):13374, 2021. †co-first author
  • Yeh YC, Ho HL, Lin CI, Chou TY, Wang YC*, “Whole-exome sequencing of Epstein–Barr virus-associated pulmonary carcinoma with low lymphocytic infiltration reveals molecular features similar to those of classic pulmonary lymphoepithelioma-like carcinoma: Evidence to support grouping together as one disease entity” American Journal of Surgical Pathology, 45(11):1476-1486, 2021.
  • Huang CJ, Wang LH, Wang YC*, “Identification of therapeutic targets for the selective killing of HBV-positive hepatocytes” Journal of Personalized Medicine, 11(7):649, 2021.
  • Chiu TY, Lin RW, Huang CJ, Yeh DW, Wang YC*, “DNA damage repair gene set as a potential biomarker for stratifying patients with high tumor mutational burden”Biology (Basel), 10(6):528, 2021.
  • Huang YF, Chang CH, Chen PJ, Lin IH, Tsai YA, Chen CF, Wang YC, Huang WY, Tsai MS*, Chen ML*, “Prenatal bisphenol A exposure, DNA methylation, and low birth weight: a pilot study in Taiwan” International Journal of Environmental Research and Public Health, 18(11):6144, 2021.
  • Wu CE, Yeh DW, Pan YR, Huang WK, Chen MH, Chang JW, Chen JS, Wang YC*, Yeh CN*, “Chromosomal instability may not be a predictor for immune checkpoint inhibitors from comprehensive bioinformatics analysis” Life (Basel), 10(11):276, 2020.
  • Pan YR†, Wu CE†, Wang YC†, Yeh YC, Lu ML, Hung YP, Chao Y, Yeh DW, Lin CH, Hsieh JCH, Chen MH, Yeh CN, “Establishment of a novel gene panel as a biomarker of immune checkpoint inhibitor response” Clinical & Translational Immunology, 9:e1145, 2020. †co-first author
  • Pan CC, Yeh YC, Wang YC, Chang YH, “Differential expression analysis of clear cell renal cell carcinomas in The Cancer Genome Atlas distinguishes an aggressive subset enriched with chromosomes 7 and 12 gains” Histopathology, 76(7):950-958, 2020.
  • Tan KT, Yeh CN, Chang YC, Cheng JH, Fang WL, Yeh YC, Wang YC, Hsu DS, Wu CE, Lai JI, Chang PM, Chen MH, Lu ML, Chen SJ, Chao Y, Hsiao M, Chen MH, “PRKDC: new biomarker and drug target for checkpoint blockade immunotherapy” Journal for ImmunoTherapy of Cancer, 8:e000485, 2020.
  • Yeh YC, Ho HL, Wu YC, Pan CC, Wang YC, Chou TY, “AKT1 internal tandem duplications and point mutations are the genetic hallmarks of sclerosing pneumocytoma” Modern Pathology, 33(3):391-403, 2020.
  • Lyu GY, Yeh YH, Yeh YC, Wang YC, “Mutation load estimation model as a predictor of the response to cancer immunotherapy” npj Genomic Medicine, 3:12, 2018.
  • Yeh YC, Lei HJ, Chen MH, Ho HL, Chiu LY, Li CP, Wang YC, “C-reactive protein (CRP) is a promising diagnostic immunohistochemical marker for intrahepatic cholangiocarcinoma and is associated with better prognosis” American Journal of Surgical Pathology, 41(12):1630-1641, 2017.
  • Hu CW, Hsu CL, Wang YC, Ishihama Y, Ku WC, Huang HC, Juan HF, “Temporal phosphoproteome dynamics induced by an ATP synthase inhibitor citreoviridin” Molecular & Cellular Proteomics, 14(12):3284-3298, 2015.
  • Lin C, Lin CN, Wang YC, Liu FY, Chien YW, Chuang YJ, Lan CY, Hsieh WP, Chen BS, “Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection” BMC Systems Biology, 8(Suppl 5):S6, 2014.
  • Lin C, Lin CN, Wang YC, Liu FY, Chuang YJ, Lan CY, Hsieh WP, Chen BS, “The role of TGF-β signaling and apoptosis in innate and adaptive immunity in zebrafish: a systems biology approach” BMC Systems Biology, 8:116, 2014.
  • Wang YC†, Tsai IC†, Lin C, Hsieh WP, Lan CY, Chuang YJ, Chen BS, “Essential functional modules for pathogenic and defensive mechanisms in Candida albicans infections” BioMed Research International, 2014:136130, 2014. †co-first author
  • Yang TH, Wang CC, Wang YC, Wu WS, “YTRP: a repository for yeast transcriptional regulatory pathways” Database: The Journal of Biological Databases and Curation, 2014:bau014, 2014.
  • Wang YC, Lin C, Chuang MT, Hsieh WP, Lan CY, Chuang YJ, Chen BS, “Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study” BMC Systems Biology, 7:79, 2013.
  • Wang YC, Huang SH, Lan CY, Chen BS, “Prediction of phenotype-associated genes via a cellular network approach: A Candida albicans infection case study” PLoS ONE, 7(4): e35339, 2012.
  • Chen BS, Chang CH, Wang YC, Wu CH, Lee HC, “Robust model matching design methodology for a stochastic synthetic gene network” Mathematical Biosciences, 230(1), 23-36, 2011.
  • Wang YC, Chen BS, “A network-based biomarker approach for molecular investigation and diagnosis of lung cancer” BMC Medical Genomics, 4:2, 2011.
  • Yang SK†, Wang YC†, Chao CC, Chuang YJ, Lan CY, Chen BS, “Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNFα-induced inflammatory responses” BMC Medical Genomics, 3:19, 2010. †co-first author
  • Wang YC, Chen BS, “Integrated cellular network of transcription regulations and protein-protein interactions” BMC Systems Biology, 4:20, 2010.
  • Wang YC, Lan CY, Hsieh WP, Murillo L, Agabian N, Chen BS, “Global screening of potential Candida albicans biofilm-related transcription factors via network comparison” BMC Bioinformatics, 11:53, 2010.
  • Chen BS, Chang YT, Wang YC, “Robust H-infinity-stabilization design in gene networks under stochastic molecular noises: fuzzy-interpolation approach” IEEE Transactions on System, Man and Cybernetics Part B: Cybernetics, 38(1), 25-42, 2008.
  • Chen BS, Wu WS, Wang YC, Li WH, “On the robust circuit design schemes of biochemical networks: steady-state approach” IEEE Transactions on Biomedical Circuits and Systems, 1(2), 91-104, 2007.
  • Chang YH, Wang YC, Chen BS, “Nonlinear dynamic trans/cis regulatory circuit for gene transcription via microarray data” Gene Regulation and Systems Biology, 1, 151-166, 2007.
  • Chang YH†, Wang YC†, Chen BS, “Identification of transcription factor cooperativity via stochastic system model” Bioinformatics, 22(18), 2276-2282, 2006. †co-first author
  • Chen BS, Wang YC, “On the attenuation and amplification of molecular noise in genetic regulatory networks” BMC Bioinformatics, 7:52, 2006.
  • Chen BS, Wang YC, Wu WS, Li WH, “A new measure of robustness of biochemical networks” Bioinformatics, 21(11), 2698-2705, 2005.