中央內容區塊
兼任師資

Hsuan-Cheng Huang

Personal Profile
Professor Hsuan-Cheng Huang Hsuan-Cheng Huang
Professor, Dept. of Computer Science and Information Engineering, NTU
PhD of Physics, National Taiwan University, Taiwan
Office:
Phone:
Email: hsuancheng@ntu.edu.tw
Personal website: http://hchuang.info/
ORCiD: 0000-0002-3386-0934

Research Interests
  • Bioinformatics
  • Computational Biology
  • Systems Biology
  • Biomedical Data Science

Publications

Journal Papers

2026

  • Huang CH, Oyang YJ, Huang HC, Juan HF. scDock: Streamlining drug discovery targeting cell-cell communication via scRNA-seq analysis and molecular docking. Bioinformatics, 42, btag103 (2026).
  • Yang CC, Lin CY, Yuan HY, Huang HC, Juan HF. Mass spectrometry-based human spatial omics: fundamentals, innovations, and applications. J. Biomed. Sci., 33, 16 (2026). (IF: 12.1)
  • Lee SC, Yu KH, Huang HC, Juan HF. Reactive oxygen species driven immune inflammation in systemic sclerosis: mechanisms and emerging therapeutics. Drug Discovery Today, 31, 104620 (2026).

2025

  • Tseng TY, Hsieh CH, Huang HC, Wu YC, Hsu C, Hsu CL, Ou DL, Juan HF. Transcriptional dynamics of CD8+ T-cell exhaustion in immune checkpoint inhibitor resistance at single-cell resolution. Mol. Cancer, 24, 306 (2025). (IF: 33.9)
  • Yu PC, Kao YC, Chang HY, Huang CH, Hsu WM, Huang HC, Juan HF. Quantitative proteomics unveils the synergistic effects of combination drugs on cytoskeleton composition and autophagy-mediated cell death in neuroblastoma. J. Proteome. Res., 24, 3578−3596 (2025).
  • Shih JC, Chen PY, Kuo CH, Hsieh CH, Chang HY, Lee HC, Huang CH, Hsu CH, Hsu WM, Huang HC, Juan HF. DHODH blockade induces ferroptosis in neuroblastoma by modulating the mevalonate pathway. Mol. Cell. Proteomics, 24, 101014 (2025).
  • Tseng TY, Hsieh CH, Liu JY, Huang HC, Juan HF. Single-cell and multi-omics integration reveals cholesterol biosynthesis as a synergistic target with HER2 in aggressive breast cancer. Comput. Struct. Biotechnol. J., 27, 1719-1731 (2025).
  • Hsieh CH, Chen YX, Tseng TY, Li A, Huang HC, Juan HF. Transcriptionally distinct malignant neuroblastoma populations show selective response to adavosertib treatment. Neurotherapeutics, 22, e00575 (2025).
  • Su YY, Huang HC, Lin YT, Chuang YF, Sheu SY, Lin CC. HEDDI-Net: heterogeneous network embedding for drug-disease association prediction and drug repurposing, with application to Alzheimer’s disease. J. Transl. Med., 23, 57 (2025). (IF: 7.5)

2024

  • Sun YY, Hsieh CY, Wen JH, Tseng TY, Huang JH, Oyang YJ, Huang HC, Juan HF. scDrug+: predicting drug-responses using single-cell transcriptomics and molecular structure. Biomed. Pharmacother. 177, 117070 (2024). (IF: 7.5)
  • Lee SC, Huang CH, Oyang YJ, Huang HC, Juan HF. Macrophages as determinants and regulators of systemic sclerosis-related interstitial lung disease. J. Transl. Med. 22, 600 (2024). (IF: 7.5)
  • Wang WH, Kao YC, Hsieh CH, Tsai SY, Cheung CHY, Huang HC, Juan HF. Multiomics reveals induction of neuroblastoma SK-N-BE(2)C cell death by mitochondrial division inhibitor 1 through multiple effects. J. Proteome Res., 23, 301-315 (2024).

2023

  • Hsieh CH, Huang CT, Cheng YS, Hsu CH, Hsu WM, Chung YH, Liu YL, Yang TS, Chien CY, Lee YH, Huang HC, Juan HF. Homoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma. Biomed. Pharmacother. 166, 115429 (2023). (IF: 7.5)
  • Ho WL, Huang HC, Huang JR. IFF: Identifying key residues in intrinsically disordered regions of proteins using machine learning. Protein Sci. 32, e4739 (2023).
  • Su YY, Liu YL, Huang HC, Lin CC. Ensemble learning model for identifying the hallmark genes of NFκB/TNF signaling pathway in cancers. J. Transl. Med. 21, 485 (2023).
  • Kao YC, Chang YW, Lai CP, Chang NW, Huang CH, Chen CS, Huang HC, Juan HF. Ectopic ATP synthase stimulates the secretion of extracellular vesicles in cancer cells. Commun. Biol. 6, 642 (2023).
  • Chang YW, Tony Yang T, Chen MC, Liaw YG, Yin CF, Lin-Yan XQ, Huang TY, Hou JT, Hung YH, Hsu CL, Huang HC, Juan HF. Spatial and temporal dynamics of ATP synthase from mitochondria toward the cell surface. Commun. Biol. 6, 427 (2023).
  • Tu YH, Juan HF, Huang HC. Context-dependent gene regulatory network reveals regulation dynamics and cell trajectories using unspliced transcripts. Brief. Bioinform., 24, bbac633 (2023). (IF: 7.7)
  • Juan HF, Huang HC. Quantitative analysis of high‐throughput biological data. WIREs Comput. Mol. Sci., 13, e1658 (2023).
  • Chen CC, Huang YW, Huang HC, Lo WC, Lyu PC. SeqCP: A sequence-based algorithm for searching circularly permuted proteins. Comput. Struct. Biotechnol. J., 21, 185-201 (2023).
  • Hsieh CY, Wen JH, Lin SM, Tseng TY, Huang JH, Huang HC, Juan HF. scDrug: From single-cell RNA-seq to drug response prediction. Comput. Struct. Biotechnol. J., 21, 150-157 (2023).
  • Chen KP, Hsu CL, Oyang YJ, Huang HC, Juan HF. BIC: a database for the transcriptional landscape of bacteria in cancer. Nucleic Acids Res., 51, D1205-D1211 (2023).

2022

  • Zhou TA, Hsu HP, Tu YH, Cheng HK, Lin CY, Chen NJ, Tsai JW, Robey EA, Huang HC, Hsu CL, Dzhagalov IL. Thymic macrophages consist of two populations with distinct localization and origin. eLife, 11, e75148 (2022).
  • Hsu CL, Yin CF, Chang YW, Fan YC, Lin SH, Wu YC, Huang HC, Juan HF. LncRNA SNHG1 regulates neuroblastoma cell fate via interactions with HDAC1/2. Cell Death Dis., 13, 809 (2022). (IF: 9.6)
  • Li A, Chen JY, Hsu CL, Oyang YJ, Huang HC, Juan HF. A single-cell network-based drug repositioning strategy for post-COVID-19 pulmonary fibrosis. Pharmaceutics, 14, 971 (2022).
  • Chang YW, Wang CC, Yin CF, Wu CH, Huang HC, Juan HF. Quantitative phosphoproteomics reveals ectopic ATP synthase on mesenchymal stem cells to promote tumor progression via ERK/c-Fos pathway activation. Mol. Cell. Proteomics., 21, 100237 (2022).
  • Yu WH, Hsu CL, Lin CC, Oyang YJ, Juan HF, Huang HC. Stratification of lncRNA modulation networks in breast cancer. BMC Medical Genomics, 14(Suppl 3), 300 (2022).
  • Yin CF, Chang YW, Huang HC, Juan HF. Targeting protein interaction networks in mitochondria dynamics for cancer therapy. Drug Discovery Today, 27, 1077-1087 (2022). (IF: 7.5)
  • Ko KY, Chen CY, Juan HF, Huang HC. Phylotranscriptomic patterns of network stochasticity and pathway dynamics during embryogenesis. Bioinformatics, 38, 763–769 (2022). (IF: 7.1)
  • Chang CS, Yu WH, Su CC, Ruan JW, Lin CM, Huang CT, Tsai YT, Lin IJ, Lai CY, Chuang TH, Lin WJ, Tan TH, Huang HC, Juan HF, Kao CY. Single-cell RNA sequencing uncovers the individual alteration of intestinal mucosal immunocytes in Dusp6 knockout mice. iScience, 25, 103738 (2022).
  • Yu PC, Huang CH, Kuo CJ, Liang PH, Wang LH, Pan MY, Chang SY, Chao TL, Ieong SM, Fang JT, Huang HC, Juan HF. Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple Targets. Pharmaceutics, 14, 176 (2022).
  • Hsieh CH, Yeh HN, Huang CT, Wang WH, Hsu WM, Huang HC, Juan HF. BI-2536 Promotes Neuroblastoma Cell Death via Minichromosome Maintenance Complex Components 2 and 10. Pharmaceuticals, 15, 37 (2022).