Chi-Ying F. Huang

• 職稱： 教授, 生物藥學研究所所長、生物醫學資訊研究所合聘、臨床醫學研究所合聘、醫學生物技術暨檢驗學系暨研究所合聘
• 學歷： 愛荷華州立大學 (Iowa State University) 生物化學及生物物理學博士
• 辦公室： 圖資大樓623室
• 電話： 886-2-28267000 ext.7904/6047/6048
• Email： cyhuang5@ym.edu.tw
• 個人網頁：個人簡歷PDF

Research Interests

• 老藥新用藥物篩選平台
  • 老藥新用藥物篩選平台：是以基因表現圖譜為基礎，首先針對疾病或藥物以基因微陣列晶片做分析，以得到疾病或藥物作用的基因表現圖譜，再透過與生物資訊的結合，利用Connectivity map－簡稱CMap，一個儲存了大量FDA 核准之老藥的基因表現圖譜的資料庫－將疾病、基因表現及藥物三者做一個連結，快速的找出治療癌症的藥物；使用CMap 除了加速藥物篩選外，從過去的藥物或已上市之藥物切入，能夠大幅降低後續臨床試驗的失敗率，更是一項關鍵的優勢。癌症治療的瓶頸在於抗藥性及高復發率，欲突破這個瓶頸我們從對抗癌症幹細胞著手，以癌症幹細胞的基因表現圖譜來比對CMap 中的資料，透過上述的篩選平台我們找到兩個小分子用藥(T2及CY001)可以有效殺死癌症幹細胞，並能克服抗藥性的問題，且其效果已在動物實驗模式上得到證實。
  • CY001：此藥在仿單核准適應症外的使用(off-label use)上發現可使數個病人的腫瘤縮小或趨於穩定的現象，目前獲得Si2C及科技部的支持進入臨床試驗，並授權給業界。
• 中草藥物的藥物研發
  • 石蓮花：近年來以中草藥作為疾病(例如慢性肝臟疾病)替代療法的例子大幅增加，我們以本土植物為開發重點，我們證實部分純化過的石蓮花對治療肝硬化及肝癌有顯著的效果，並與生技中心合作進行製程放大與管控(CMC)後，此項專利目前已授權業界，陽明分得33%。
  • YQ1：現今認為化療產生的抗藥性和助於腫瘤生長的癌症幹細胞，這都是癌症病人治療失敗和腫瘤復發的主要因素。透過基因微陣列技術、CMap 和LINCS 的分析，發現以黃耆為底的複方(以YQ1 表示)可能與癌症幹細胞、EGFR 的訊息傳遞和免疫反應有關。細胞實驗的結果指出YQ1 能夠抑制肺癌細胞株的各種能力，並能克服抗藥性的問題。在老鼠實驗中，cisplatin 搭配YQ1 可以明顯的抑制腫瘤的生長。此外，在YQ1 搭配化療藥物相較於單獨化療的治療會有較顯著的延長肺癌病人存活時間。本團隊的未來目標是將YQ1 建立為癌症幹細胞的抑制劑，並與業界準備向美國提出新藥臨床試驗申請。目前陽明大學與長庚醫院共同與業界洽談技轉中。

Publications

5.       Cheng-Yan Kao, D. Frank Hsu, Han-Yu Chuang, Chi-Ying F. Huang, and Kuang-Chi Chen. To combine or not to combine. International Chinese Statistical Association Bulletin, 37-39 (2004).

6.       Tao-Wei Huang, An-Chi Tien, Wen-Shien Huang, Yuan-Chii G. Lee, Chin-Lin Peng, Huei-Hun Tseng, Cheng-Yan Kao, and Chi-Ying F. Huang*. POINT: a database for the prediction of protein-protein interactions based on the orthologous interactome. Bioinformatics 20, 3273-3276 (2004).

7.       Jiunn-Chyi Wu, Tzong-Yueh Chen, Chang-Tze R. Yu, Si-Jie Tsai, Jung-Mao Hsu, Ming-Jer Tang, Chen-Kung Chou, Wey-Jinq Lin, Chiun-Jye Yuan and Chi-Ying F. Huang*. Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening. J. Biol. Chem. 280, 9013-9022 (2005).

8.       Chi-Chih Cheng, Shu-Mei Yang, Chi-Ying F. Huang, Jung-Chou Chen, Wei-Mao Chang, and Shih-Lan Hsu. Molecular mechanisms of ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells. Cancer Chemotherapy and Pharmacology 55, 531-40 (2005).

9.       Te-Jung Lu, Chi-Ying F. Huang, Chiun-Jye Yuan, Yuan-Chii Lee, Tzeng-Horng Leu, Wen-Chang Chang, Te-Ling Lu, Wen-Yih Jeng, Ming-Derg Lai. Zinc ion acts as a cofactor for serine/threonine kinase MST3 and has a distinct role in autophosphorylation of MST3. J. Inorg. Biochem. 99, 1306-1313 (2005).

10.    Chang-Tze Ricky Yu, Jung-Mao Hsu, Yuan-Chii Gladys Lee, Ann-Ping Tsou, Chen-Kung Chou and Chi-Ying F. Huang. Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. Mol. Cell. Biol. 25, 5789-5800 (2005).

11.    Kuang-Chi Chen, Tse-Yi Wang, Huei-Hun Tseng, Chi-Ying F. Huang and Cheng-Yan Kao. A stochastic differential equation model for quantifying transcriptional regulatory network in Saccharomyces cerevisiae. Bioinformatics 21, 2883-2890 (2005).

12.    Kuo-Ting Chang, Chi-Ying F. Huang, Chun-Ming Tsai, Chao-Hua Chiu and Ying-Yung Lok. Role of IL-6 in Neuroendocrine Differentiation and Chemosensitivity of Non-Small Cell Lung Cancer. American Journal of Physiology: Lung Cellular and Molecular Physiology 289, 438-445 (2005).

13.    Kuo-Ting Chang, Chun-Ming Tsai, Yih-Chy Chiou, Chao-Hua Chiu, King-Song Jeng and Chi-Ying F. Huang. IL-6 induces neuroendocrine de-differentiation and cell proliferation in non-small cell lung cancer cells. American Journal of Physiology: Lung Cellular and Molecular Physiology 289, 446-453 (2005).

14.    Yong-Shiang Lin, Li-Jen Su, Chang-Tze Ricky Yu, Fen-Hwa Wong, Hsu-Hua Yeh, Su-Liang Chen, Jiunn-Chyi Wu, Wey-Jinq Lin, Yow-Ling Shiue, Hsiao- Sheng Liu, Shih-Lan Hsu, Jin-Mei Lai and Chi-Ying F. Huang. Gene Expression Profiles of the Aurora Family Kinases. Gene Expression 13, 15-26 (2006).

15.    Shih-Lan Hsu, Chang-Tze Ricky Yu, Sui-Chu Yin, Ming-Jer Tang, An-Chi Tien, Yi-Mi Wu, and Chi-Ying F. Huang. Caspase 3, periodically expressed and activated at G2/M transition, is required for nocodazole-induced mitotic checkpoint. Apoptosis 11, 765-771 (2006).

16.    Cheng-Ming Lee, Shih-Yin Chen, Yuan-Chii G. Lee, Chi-Ying F. Huang and Yi-Ming Arthur Chen. Benzo[a]pyrene and Glycine N-methyltransferse Interactions: Gene Expression Profiles of the Liver Detoxification Pathway. Toxicology and Applied Pharmacology 214, 126-135 (2006).

17.    Li-Jen Su, Shih-Lan Hsu, Jyh-Shyue Yang, Huei-Hun Tseng, Shiu-Feng Huang, and Chi-Ying F. Huang. Global gene expression profiling of dimethylnitrosamine induced liver fibrosis: from pathological and biochemical data to microarray analysis. Gene Expression 13, 107-132 (2006).

18.    He-Yen Chou, Shen-Long Howng, Tai-Shan Cheng, Yun-Ling Hsiao, Ann-Shung Lieu, Joon-Khim Loh, Shiuh-Lin Hwang, Ching-Chih Lin, Ching-Mei Hsu, Chihuei Wang, Chu-I Lee, Pei-Jung Lu, Chen-Kung Chou, Chi-Ying F. Huang and Yi-Ren Hong. GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta. Biochemistry 45, 11379-11389 (2006).

19.    Ya-Shih Tseng, Ching-Cherng Tzeng, Chi-Ying F. Huang, Ping-Hong Chen, Allen Wen-Hsiang Chiu, Pei-Yin Hsu, Guan-Cheng Huang, Yu-Chun Wang, Hsiao-Sheng Liu. Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer. Cancer Letters 241, 93-101 (2006).

20.    Te-Jung Lu, Wen-Yang Lai, Chi-Ying F. Huang, Wan-Jung Hsieh, Jau-Song Yu, Ya-Ju Hsieh, Wen-Tsan Chang, Tzeng-Horng Leu, Wen-Chang Chang, Woei-Jer Chuang, Ming-Jer Tang, Tzong-Yueh Chen, Te-Ling Lu, Ming-Derg Lai. Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein tyrosine phosphatase (PTP)-PEST. J. Biol. Chem. 281, 38405-38417 (2006).

21.    Yuan-Chii Gladys Lee, Yu-Chyi Hwang, Kuang-Chi Chen, Yong-Shiang Lin, Dah-Yeou Huang, Tao-Wei Huang, Cheng-Yan Kao, Han-Chung Wu, Chin-Tarng Lin, Chi-Ying F. Huang. Effect of Epstein-Barr Virus Infection on Global Gene Expression in Nasopharyngeal Carcinoma. Functional and Integrative Genomics 7, 79-93 (2007).

22.    Kuan-Yu Chen, Yuan-Chii Gladys Lee, Jin-Mei Lai, Yih-Leong Chang, Yung-Chie Lee, Chong-Jen Yu, Chi-Ying F. Huang*, Pan-Chyr Yang*. Identification of Trophinin as an Enhancer for Cell Invasion and a Prognostic Factor for Early Stage Lung Cancer. European Journal of Cancer 43, 782-90 (2007). (*corresponding author)

23.    Tai-Shan Cheng, Yun-Ling Hsiao, Ching-Chih Lin, Ching-Mei Hsu, Mau-Sun Chang, Chu-I Lee, Ricky Chang-Tze Yu, Chi-Ying F. Huang, Shen-Long Howng, and Yi-Ren Hong. hNinein is required for targeting spindle-associated protein Astrin to the centrosome during the S and G2 phases. Exp. Cell. Res. 313, 1710-1721 (2007).

24.    Chun-Nan Hsu, Jin-Mei Lai, Chia-Hung Liu, Huei-Hun Tseng, Chih-Yun Lin, Kuan-Ting Lin, Hsu-Hua Yeh, Ting-Yi Sung, Wen-Lian Hsu, Li-Jen Su, Sheng-An Lee, Chan-Han Chen, Gen-Cher Lee, Der-Tsai Lee, Yow-Ling Shiue, Chang-Wei Yeh, Chao-Hui Chang, Cheng-Yan Kao, Chi-Ying F. Huang. Detection of the inferred interaction network in hepatocellular carcinoma from EHCO (Encyclopedia of Hepatocellular Carcinoma genes Online). BMC Bioinformatics 8, 66 (2007).

25.    Chang-Han Chen, Pei-Jung Lu, Yu-Chia Chen, Shu-Ling Fu, Kou-Juey Wu, Ann-Ping Tsou, Yuan-Chii Gladys Lee, Tsu-Chun Emma Lin, Shih-Lan Hsu, Wey-Jinq Lin, Chi-Ying F. Huang* and Chen-Kung Chou*. FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway. Oncogene 26, 4272-4283 (2007) (*corresponding author)

26.    Li-Jen Su, Ching-Wei Chang, Yu-Chung Wu, Kuang-Chi Chen, Chien-Ju Lin, Shu-Ching Liang, Chi-Hung Lin, Jacqueline Whang-Peng, Shih-Lan Hsu, Chen-Hsin Chen and Chi-Ying F. Huang. Selection of DDX5 as a Novel Internal Control for Q-RT-PCR from microarray data: Using a Block Bootstrap Re-sampling scheme. BMC Genomics 8(1),140 (2007).

27.    Chueh-Chuan Yen, Shu-Ching Liang, Yiin-Jeng Jong, Yann-Jang Chen, Chi-Hung Lin, Yuh-Min Chen, Yu-Chung Wu, Wu-Chou Su, Chi-Ying F. Huang, Szu-Wen Tseng and Jacqueline Whang-Peng. Chromosomal aberrations of malignant pleural effusions of lung adenocarcinoma: Different cytogenetic changes are correlated with genders and smoking habits. Lung Cancer Sep;57(3):292-301 (2007).

28.    Wei-Li Wang, Sheau-Farn Yeh, Eagle Yi-Kung Huang, Yu-Ling Lu, Chun-Fa Wang, Chi-Ying F. Huang and Wey-Jinq Lin. Mitochondrial anchoring of PKCa by PICK1 confers resistance to etoposide-induced apoptosis. Apoptosis Oct. 12(10):1857-71 (2007).

29.    Chang-Tze Ricky Yu, Jiunn-Chyi Wu, Mei-Chih Liao, Shih-Lan Hsu and Chi-Ying F. Huang. Identification of c-Fos as a mitotic phosphoprotein: regulation of c-Fos by Aurora-A. J. Biomedical Sci. 15:79-87 (2008).

30.    Pao-Ling Torng, Yuan-Chii G. Lee, Chi-Ying F. Huang, Y. H. Ye, Yong-Shiang Lin, Yi-Wen Chu, Su-Cheng Huang, Pinchas Cohen, Cheng-Wen Wu, Chin-Tarng Lin. Insulin-like grow factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma. Oncogene 3:2137-2147 (2008).

31.    Tai-Shan Cheng, Yun-Ling Hsiao, Ching-Chih Lin, Ricky Chang-Tze Yu, Ching-Mei Hsu, Mau-Sun Chang, Chu-I Lee, Chi-Ying F. Huang, Shen-Long Howng, and Yi-Ren Hong. Glycogen synthase kinase 3beta interacts with and phosphorylates the spindle-associated protein astrin. J. Biol. Chem 283(4):2454-2464 (2008).

32.    Dah-Yeou Huang, Yi-Ting Lin, Pey-Shynan Jan, Yu-Chyi Hwang, Sung-Tzu Liang, Yeh Peng, Chi-Ying F. Huang, Han-Chung Wu and Chin-Tang Lin. Transcription factor SOX-5 enhances nasopharyngeal carcinoma progression by downregulating SPARC gene expression. J. Pathology 214(4): 445-455 (2008).

33.    Chia-Ying Yang, Chao-Hui Chang, Tsu-Chun Emma Lin, Ya-Ling Yu, Sheng-An Lee, Chueh-Chuan Yen, Jinn-Moon Yang, Jin-Mei Lai, Yi-Ren Hong, Tzu-Ling Tseng, Kun-Mao Chao and Chi-Ying F. Huang. PhosphoPOINT: a comprehensive human kinase interactome and phospho-protein database. Bioinformatics 24, i14-i20 (2008).

34.    Sheng-An Lee, Cheng-hsiung Chan, Chi-Hung Tsai, Jin-Mei Lai, Feng-Sheng Wang, Cheng-Yan Kao and Chi-Ying F. Huang. Ortholog-based protein-protein interaction prediction and its application to inter-species interactions. BMC Bioinformatics 9(Suppl 12):S11 (2008).

35.    Fen-Hwa Wong#, Chi-Ying F. Huang#, Li-Jen Su, Yu-Chung Wu, Yong-Shiang Lin, Jiun-Yi Hsia, Hsin-Ting Tsai, Sheng-An Lee, Chi-Hung Lin, Cheng-Hwai Tzeng, Po-Min Chen, Yann-Jan Chen, Shu-Ching Liang, Jin-Mei Lai, and Chueh-Chuan Yen. Combination of microarray profiling and protein-protein interaction databases delineates the minimal discriminators as a metastasis network for esophageal squamous cell carcinoma. Int J Oncology 34: 117-128 (2009). (#contributed equally)

36.    Zhong-Zhe Lin, Hey-Chi Hsu, Chih-Hung Hsu, Pei-Yen Yeh, Chi-Ying F. Huang, Yung-Feng Huang, Te-Jung Chen, Sung-Hsin Kuo, Chiun Hsu, Fu-Chang Hu, Yung-Ming Jeng, Ying Chung, and Ann-Lii Cheng. The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma. J. Hepatology 50(3): 518-527 (2009).

37.    Chang-Han Chen, Jin-Mei Lai, Teh-Ying Chou, Cheng-Yu Chen, Li-Jen Su, Yuan-Chii Lee, Tai-Shan Cheng, Yi-Ren Hong, Jacqueline Whang-Peng, Chen-Kung Chou, Yu-Chung Wu, and Chi-Ying F. Huang. VEGFA upregulates FLJ10540 and modulates migration and invasion of lung cancer via PI3K/AKT pathway. PLoS ONE 4(4): e5052 (2009).

38.    Sheng-An Lee, Chen-Hsiung Chan, Tzu-Chi Chen, Chia-Ying Yang, Kuo-Chuan Huang, Chi-Hung Tsai, Jin-Mei Lai, Feng-Sheng Wang, Cheng-Yan Kao, Chi-Ying F. Huang. POINeT: Protein Interactome with Sub-network Analysis and Hub Prioritization. BMC Bioinformatics 10:114 (2009).

39.    Chang-Han Chen, Chih-Yen Chien, Chao-Cheng Huang, Hui-Ching Chuang, Fu-Min Fang, Hsuan-Ying Huang, Ching-Mei Chen, Hsin-Ling Liu and Chi-Ying F. Huang. Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion via increased FOXM1 and MMP-2 activity. Oncogene 28, 2723-2737 (2009).

40.    Tzu-Chi Chen, Sheng-An Lee, Chen-Hsiung Chan, Yue-Li Juang, Yi-Ren Hong, Yi-Shann Huang, Jin-Mei Lai, Cheng-Yan Kao, and Chi-Ying F. Huang. Cliques in mitotic spindle network bring kinetochore-associated complexes to form dependence pathway. Proteomics 9, 4048-4062 (2009) (with a figure selected as journal cover.)

41.    Shun-Fu Chen, Yue-Li Juang, Wei-Kang Chou, Jin-Mei Lai, Chi-Ying F Huang*, Cheng-Yan Kao, and Feng-Sheng Wang*. Inferring a transcriptional regulatory network of the cytokinesis-related genes by network component analysis. BMC Systems Biology 3:110 (2009). (*corresponding author)

42.    Tzu-Chi Chen, Sheng-An Lee, Tse-Ming Hong, Jin-Yuan Shih, Jin-Mei Lai, Hsin-Ying Chiou, Shuenn-Chen Yang, Chen-Hsiung Chan, Cheng-Yan Kao, Pan-Chyr Yang and Chi-Ying F. Huang. From midbody protein-protein interaction network construction to novel regulators in cytokinesis. Journal of Proteome Research 8, 4943-4953 (2009).

43.    Ya-Shih Tseng, Jheng-Chang Lee, Chi-Ying F. Huang and Hsiao-Sheng Liu. Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway. BMC Cancer 9:435 (2009).

44.    Ferrell JE, Pomerening JR, Kim SY, Trunnell NB, Xiong W, Huang CY, Machleder EM. Simple, realistic models of complex biological processes: positive feedback and bistability in a cell fate switch and a cell cycle oscillator. FEBS Lett. 583 (24): 3999-4005 (2009)

45.    Huang CW, Lin CY, Huang HY, Liu HW, Chen YJ, Shih DF, Chen HY, Juan CC, Ker CG, Huang CY, Li CF, Shiue YL. CKS1B overexpression implicates clinical aggressiveness of hepatocellular carcinomas but not p27(Kip1) protein turnover: an independent prognosticator with potential p27 (Kip1)-independent oncogenic attributes? Ann Surg Oncol. 17(3):907-22 (2010).

46.    Ann-Shung Lieu, Tai-Shan Cheng, Chia-Hua Chou, Chia-Hung Wu, Chia-Yi Hsu, Chi-Ying F. Huang, Li-Kwan Chang, Joon-Khim Loh, Chung-Shing Chang,Ching-Mei Hsu, Shen-Long Howng And Yi-Ren Hong. Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation. International Journal Of Oncology (37): 429-436 (2010)

47.    Yu-Chung Wu, Li-Jen Su, Hao-Wei Wang, Chien-Fu Jeff Lin, Wen-Hu Hsu, Teh-Ying Chou, Chi-Ying F. Huang, Chia-Li Lu, and Chung-Tsen Hsueh. Cooverexpression of Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Adversely Affects the Postoperative Survival in Non-small Cell Lung Cancer. Journal of Thoracic Oncology 5(8):1167-74 (2010).

48.    Yun-Chih Hsieh, Yerra Koteswara Rao, Chun-Chi Wu, Chi-Ying F. Huang, Madamanchi Geethangili, Shih-Lan Hsu, and Yew-Min Tzeng. Methyl Antcinate A from Antrodia camphorata Induces Apoptosis in Human Liver Cancer Cells through Oxidant-Mediated Cofilin- and Bax-Triggered Mitochondrial Pathway. Chem Res Toxicol. 23(7):1256-67 (2010).

49.    Yin-Ju Chen, Yu-Hsuan Chen, Lu-Ping Chow, Ya-Hui Tsai, Pei-Hong Chen, Chi-Ying F. Huang, Wei-Tzu Chen, and Lih-Hwa Hwang. Heat shock protein 72 is associated with the hepatitis C virus replicase complex and enhances viral RNA replication. J Biol Chem 285, 28183-28190 (2010).

50.    Ming-Ying Lan, Chi-Long Chen, Kuan-Ting Lin, Sheng-An Lee, Wu-Lung R. Yang, Chun-Nan Hsu, Jaw-Ching Wu, Ching-Yin Ho, Jin-Ching Lin, Chi-Ying F. Huang. From NPC Therapeutic Target Identification to Potential Treatment Strategy. Molecular Cancer Therapeutics 9(9):2511-23 (2010).

51.    Chia-Hung Liu#, Kuan-Ting Lin#, Chi-Ying F. Huang#, Yih-Jyh Shann, Yu-Shi Lin, Cheng-Yan Kao, Chun-Nan Hsu. Genome-Wide Detection of Putative Oncofetal Genes in Human Hepatocellular Carcinoma by Splicing Pattern Comparison. iConcept Transaction on Computational Intelligence in Bioinformatics, 2:1, iConcept Press (2010) (#contributed equally)

52.    Sheng-Da Hsu, Feng-Mao Lin, Wei-Yun Wu, Chao Liang, Wei-Chih Huang, Wen-Ling Chan, Wen-Ting Tsai, Goun-Zhou Chen, Chia-Jung Lee, Chih-Min Chiu, Chia-Hung Chien, Ming-Chia Wu, Chi-Ying Huang, Ann-Ping Tsou and Hsien-Da Huang. miRTarBase: a database curates experimentally validated microRNA-target interactions. Nucleic Acids Research 39:D163-D169 (2011).

53.    Yuan-I Chang, Sheng-Chieh Hsu, Gar-Yang Chau, Chi-Ying F. Huang, Jung-Sung Sung, Wei-Kai Hua, Wey-Jinq Lin. Identification of the methylation preference region in heterogeneous nuclear ribonucleoprotein K by protein arginine methyltransferase 1 and its implication in regulating nuclear/cytoplasmic distribution. Biochemical and Biophysical Research Communications 404:865-869 (2011).

54.    Hsien-Chia Juan, Hsin-Ting Tsai, Po-Hao Chang, Chi-Ying F. Huang, Cheng-Po Hu and Fen-Hwa Wong. Insulin-like growth factor 1 mediates 5-fluorouracil chemoresistance in esophageal carcinoma cells through increasing survivin stability. Apoptosis 16:174-183 (2011).

55.    Chien-Chung Lin, Lien-Chin Chen, Vincent S. Tseng, Jing-Jou Yan, Wu-Wei Lai, Wen-Pin Su, Chi-Hung Lin, Chi-Ying F. Huang, and Wu-Chou Su. Malignant pleural effusion cells show aberrant glucose metabolism gene expression. European Respiratory Journal 37: 1453-1465 (2011).

56.    Yu-Ying Lin, Chun-Hung Yang, Gwo-Tarng Sheu, Chi-Ying F. Huang, Yu-Chung Wu, Shu-Ming Chuang, Ming-Ji Fann, Han Chang, Huei Lee, Jinghua Tsai Chang. A novel exon 15-deleted, splicing variant of slit2 shows potential for growth inhibition in addition to invasion inhibition in lung cancer. Cancer 117(15): 3404-15 (2011).

57.    Jiz-Yuh Wang, Chi-Ling Yeh, Hsiao-Chin Chou, Chi-Hwa Yang, Yu-Ning Fu, Ya-Ting Chen, Hui-Wen Cheng, Chi-Ying F. Huang, Hui-Ping Liu, Shiu-Feng Huang and Yi-Rong Chen. Vaccinia H1-related phosphatase (VHR) is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancer. The Journal of Biological Chemistry 286(12): 10177-10184 (2011).

58.    Yei-Hsuan Huang, Chun-Chi Wu, Chen-Kung Chou, and Chi-Ying F. Huang. A Translational Regulator, PUM2, Promotes both Protein Stability and Kinase Activity of Aurora-A. PLoS ONE 6(5): e19718 (2011)

59.    Kai-Wei Hsueh, Shu-Ling Fu, Chi-Ying F. Huang, Chao-Hsiung Lin. Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53. FEBS Letters 585, 2671-2675 (2011).

60.    Hsiao-Sheng Liu, Ching-Shiun Ke, Hung-Chi Cheng, Chi-Ying F. Huang, and Chun-Li Su. Curcumin-induced Mitotic Spindle Defect and Cell Cycle Arrest in Human Bladder Cancer Cells is partly through Inhibition of Aurora-A. Mol. Pharmacol. 80: 638-646 (2011).

61.    Yun-Chih Hsieh, Yerra Koteswara Rao, Jacqueline Whang-Peng, Chi-Ying F. Huang, Song-Kun Shyue, Shih-Lan Hsu, and Yew-Min Tzeng. Antcin B and Its Ester Derivative from Antrodia camphorata Induce Apoptosis in Hepatocellular Carcinoma Cells Involves Enhancing Oxidative Stress Coincident with Activation of Intrinsic and Extrinsic Apoptotic Pathway. J. Agric. Food Chem. 59, 10943-10954 (2011).

62.    Ming-Huang Chen, Wu-Lung R. Yang, Kuan-Ting Lin, Chia-Hung Liu,  Yu-Wen Liu, Kai-Wen Huang, Peter Mu-Hsin Chang, Jin-Mei Lai, Chun-Nan Hsu, Kun-Mao Chao, Cheng-Yan Kao, Chi-Ying F. Huang. Gene Expression-Based Chemical Genomics Identifies Potential Therapeutic Drugs in Hepatocellular Carcinoma. PLoS ONE 6(11): e27186 (2011).

63. Yu-Liang Lee, Jie-Wei Weng, Wen-Chin Chiang,Yi-Wen Lin, Ka-Lok Ng*, Jeffrey Jing-Pha Tsai, Chi-Ying F. Huang*.Investigating Cancer-related Proteins Specific Domain Interactions and Differential Protein Interactions caused by Alternative Splicing.IEEE International Conference on Bioinformatics andBioengineering BIBE 2011, 1(1), 33-38 (2011) (EI)

64. Chang-Tze Yu, Jiun-Yi Hsia, Yun-Chih Hseih, Li-Jen Su, Tien-Chiang Lee, Chia-Feng Ku, Ke-Shin Chen, Jou-May Chen, Tong-You Wei, Yuan-Chii Lee, Chi-Ying F. Huang, Yu-Chung Wu, Chiou-Ying Yang, Shih-Lan Hsu. The novel protein suppressed in lung cancer down-regulated in lung cancer tissues retards cell proliferation and inhibits the oncokinase Aurora-A. Journal of Thoracic Oncology 6(6):988-97. (2011)

65. Yu-Yu Lin, Yung-Ho Hsu, Hsin-Yi Huang, Yih-Jyh Shann, Chi-Ying F. Huang, Shu-Chen Wei, Chi-Ling Chen, and Tzuu-Shuh Jou. Aberrant nuclear localization of EBP50 promotes colorectal carcinogenesis in xenotransplanted mice by modulating TCF-1 and β-catenin interactions. Journal of Clinical Investigation 122(5): 1881-1894 (2012).

66. Li-Jen Su, Chih-Hsueh Yang, Shiu-FengHuang, Ya-Ling Yuo, Hui-Chu Hsieh, Tzu-Ling Tseng, Chang-Han Chen, Shih-Lan Hsu*and Chi-Ying F. Huang*. Evaluationofthe Chinese medicinal herb, Graptopetalum paraguayense, as a therapeutic treatment for liver damage in rat models. Evidence-Based Complementary and Alternative Medicine2012 (*contributed equally) (2012)

67. Chang-Han Chen, Li-Yen Shiu, Li-Jen Su, Chi-Ying F. Huang, Shun-Chen Huang, Chao-Cheng Huang, Yu-Fang Yin, Wei-Sheng Wang, Hsin-Ting Tsai, Fu-Min Fang, Wan-Chu Chuang, Hong-Chang Kang and Chung-Feng Hwang. FLJ10540 is associated with tumor progression in nasopharyngeal carcinomas and contributes to nasopharyngeal cell proliferation and metastasis via the osteopontin/CD44 pathway. Journal ofTranslational Medicine10(1): 93(2012).

68. Yi-Hua Jan, Hong-Yuan Tsai, Chih-Jen Yang, Ming- Shyan Huang, Yi-Fang Yang, Tsung-Ching Lai, Chien-Hsin Lee, Yung-Ming Jeng, Chi-Ying F. Huang, Jen-Liang Su, Yung-Jen Chuang, and Michael Hsiao. Adenylate kinase-4 is a marker of poor clinical outcomes that promotes metastasis of lung cancer by downregulating the transcription factor ATF3. Cancer Research 72(19):5119-29 (2012)

69. Chi-Tai Yeh, Alexander TH Wu,Peter M-H Chang,Kuan-Yu Chen, Chia-Ning Yang, Shuenn-Chen Yang, Chao-Chi Ho, Chun-Chi Chen, Yu-Lun Kuo,Pei-Ying Lee,Yu-Wen Liu, Chueh-Chuan Yen, Michael Hsiao, Pei-Jung Lu, Jin-Mei Lai, Liang-Shun Wang, Chih-Hsiung Wu, Jeng-Fong Chiou, Pan-Chyr Yang*, and Chi-Ying F. Huang*.Trifluoperazine, an antipsychotic agent, inhibits cancer stem cell growth and overcomesdrug resistance of lung cancer. American Journal of Respiratory and Critical Care Medicine186(11):1180-8 (2012)(*corresponding author)

70. Chia-Ping Shen, Chia-Hung Liu, Feng-Sheng Lin, Han Lin, Chi-Ying F. Huang, Cheng-Yan Kao, Feipei Lai, Jeng-Wei Lin.A multiclass classification tool using cloud computing architecture. Proceedings of the 2012 IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining, ASONAM 2012 6425667:765-770. (2012)

71. Chu-I Lee, An-Kuo Chou, Ching-Chih Lin, Chia-Hua Chou, Joon-Khim Loh, Ann Shung Lieu, Chih-Jen Wang, Chi-Ying F. Huang, Shen-Long Howng, Yi-Ren Hong.Immune and inflammatory gene signature in rat cerebrum in subarachnoid hemorrhage with microarray analysis. Molecular Medicine Reports5(1):118-125. (2012)

72. Wu-Lung R. Yang, Yu-En Lee, Ming-Huang Chen, Kun-Mao Chao*, Chi-Ying F. Huang*. In-silico drug screening and potential target identification for hepatocellular carcinoma using Support Vector Machines based on drug screening result. Gene 518:201-8 (2013) (*corresponding author)

73. Ming-Huang Chen, Yi-Chen Yeh, Yee Chao, Chung-Pin Li, Yi-Ming Shyr, Shin-e Wang, Cheng-Hwai Tzeng, Peter Mu-Hsin Chang, Chun-Yu Liu, Ming-Han Chen, Michael Hsiao*and Chi-Ying F. Huang*. Expression of Gremlin 1 (GREM1) Correlated With Increased Angiogenesis and Increased Progression-Free Survival in Patients with Pancreatic Neuroendocrine Tumors. Journal of Gastroenterology48(1):101-8 (2013)(*corresponding author)

74. Ming-Huang Chen, Kun-Ju Lin, Wu-Lung R. Yang, Ya-Wen Kao, Tsung-Wen Chen, Shu-Chaou Chao, Peter Mu-Hsin Chang, Chun-Yu Liu, Cheng-Hwai Tzeng, Yee Chao, Ming-Han Chen, Chun-Nan Yeh*, and Chi-Ying F. Huang*. Gene Expression-Based Chemical Genomics Identifies Heat ShockProtein 90 Inhibitors as Potential Therapeutic Drugs in Cholangiocarcinoma. Cancer119(2):293-303 (2013)(*corresponding author)

75. Li-Jen Su, Chia-Chuan Chang, Chih-Hsueh Yang, Shur-Jong Hsieh, Yi-Chin Wu, Jin-Mei Lai, Tzu-Ling Tseng, Chi-Ying F. Huang*, and Shih-Lan Hsu*. Graptopetalum paraguayense ameliorates chemical-induced rat hepatic fibrosis in vivo and inactivates stellate cells and Kupffer cells in vitro. PLOS ONE8(1): e53988(2013)

76. Yu-Cheng Lee, Po-Chi Liao, Yih-Cherng Liou, Michael Hsiao, Chi-Ying Huang*, and Pei-Jung Lu*.Glycogen synthase kinase 3 β activity is required for hBora/Aurora A-mediated mitotic entry. Cell Cycle12(6):1-8 (2013) (*corresponding author)

77. Pei-Ying Lee, Chi-Long Chen, Zhong-Zhe Lin, Ann-Lii Cheng, Edmund I-Tsuen Chen, Jacqueline Whang-Peng and Chi-Ying F. Huang*. The Aurora kinases inhibitor VE-465 is a novel treatment for glioblastoma multiforme. Oncology84(6):326-35(2013)

78. Tzu-Chi Chen, Yu-Wen Liu, Yei-Hsuan Huang, Yi-Chen Yeh, Teh-Ying Chou, Yu-Chung Wu, Chun-Chi Wu, Yi-Rong Chen, Hui-Chuan Cheng, Pei-Jung Lu, Jin-Mei Lai, Chi-Ying F. Huang*. Protein phosphorylation profiling via in situ proximity ligation assay: implication of AURKA-elicited EGFR-Thr654 and EGFR-Ser1046 phosphorylation in EGFR mutant cells.PLOS ONE8(3):e55657 (2013)

79. Chia-Hung Liu, Tzu-Chi Chen, Gar-Yang Chau, Yi-Hua Jan, Chun-Houh Chen, Chun-Nan Hsu, Kuan-Ting Lin, Yue-Li Juang, Pei-Jung Lu, Hui-Chuan Cheng,Ming-Huang Chen, Chia-Fen Chang, Yu-Shan Ting, Cheng-Yan Kao*, Michael Hsiao*, and Chi-Ying F. Huang*. Analysis of Protein-Protein Interactions in Cross-talk Pathways Reveals CRKL Protein as a Novel Prognostic Marker in Hepatocellular Carcinoma.Molecular and Cellular Proteomics12(5):1335-49 (2013)

80. Jiun-Ming Wu, Chiung-Tong Chen, Mohane Selvaraj Coumar, Wen-Hsin Lin, Zi-Jie Chen, John T.-A. Hsu, Yi-Hui Peng, Hui-Yi Shiao, Wen-Hsing Lin, Chang-Ying Chu, Jian-Sung Wu, Chih-Tsung Lin, Ching-Ping Chen, Ching-Cheng Hsueh, Kai-Yen Chang, Li-Pin Kao, Chi-Ying F. Huang, Yu-Sheng Chao, Su-Ying Wu, Hsing-Pang Hsieh, and Ya-Hui Chi. Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules. Proceedings of the National Academy of Sciences of the United States of America110(19):E1779-87(2013)(Published online)

81. Yu-Feng Hu, Tzu-Chi Chen, Gar-Yang Chau, Tsung-Lin Yang, Chia-Jen Liu, Ming-Huang Chen, Peter Mu-hsin Chang, Tzeng-Ji Chen, Michael Hsiao, Chi-Ying F. Huang* and Shih-Ann Chen*. Baseline hypertension: New insight into the potential predictors of survival in patients with hepatocellular carcinoma.International Journal of Cardiology168(3):2979–2981(2013)(*contributed equally)

82. Chien-Hung Huang, Min-You Wu, Chi-Ying F. Huang, and Ka-Lok Ng. Therapeutic target identification for lung cancer, international conference on bioinformatics (ICB’13) (2013) (EI)

83. Mu-Hsin Peter Chang, Yi-Chen Yeh, Tzu-Chi Chen, Yu-Chung Wu, Pei-Jung Lu, Hui-Chuan Cheng, Hsueh-Ju Lu, Ming-Huang Chen, Teh-Ying Chou, Chi-Ying F. Huang*. High expression of CHRNA1 is associated with reduced survival in early stage lung adenocarcinoma after complete resection. Annals of Surgical Oncology20:3648-3654 (2013)

84. Chi-Tai Yeh, Chun-Li Su, Chi-Ying F. Huang, Justin Kung-Yi Lin, Wei-Hwa Lee, PeterM.-H. Chang, Yu-Lun Kuo, Yu-Wen Liu, Liang-Shun Wang, Chih-HsiungWu, Yi-Shing Shieh, Yi-Hua Jan,Yung-Jen Chuang, Michael Hsiao, and Alexander T. H.Wu. A Preclinical Evaluation of Antimycin A as a Potential Antilung Cancer Stem Cell Agent. Evidence-Based Complementary and Alternative Medicine2013.(2013).

85. Chih-Cheng Chen, Chia-Bao Chu, Ko-Jiunn Liu, Chi-Ying F. Huang, Jang-Yang Chang, Wen-Yu Pan, Huang-Hui Chen, Yun-Hsia Cheng, Kuan-Der Lee, Miao-Fen Chen, Ching-Chuan Kuo, Li-Tzong Chen. Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: The role of IL-6signaling and Nrf2/AKR1C axis identification. Biochemical Pharmacology86(7):872–887 (2013).

86. Yu-Cheng Lee, Jenny Que, Yu-Chia Chen, Jen-Tai Lin, Yih-Cherng Liou, Po-Chi Liao, Yu-Peng Liu, Kuen-Haur Lee, Li-Ching Lin, Michael Hsiao, Liang-Yi Hung, Chi-Ying Huang* and Pei-Jung Lu*. Pin1 acts as a negative regulator of the G2/M transition through an interplay with the Aurora A/hBora complex. Journal of Cell Science126:4862-4872 (2013).(*contributed equally)

87. Pi-Lin Sung, Eong-Eong Cheng, Yann-Jang Chen, Schu-Rern Chern, Chung-Yu Shih, Chia-Ming Chang, Peng-Hui Wang, Ming-Shyen Yen, Chi-Ying F. Huang, Chih-Ping Chen. Prenatal diagnosis of de novo monosomy 7q33-qter associated with hydrops fetalis, semilobar holoprosencephaly, and premaxillary dysgenesis.Taiwanese Journal of Obstetrics and Gynecology52 (4):602-606. (2013)

88. Chi-Tai Yeh, Wen-Chien Huang, Yerra Koteswara Rao, Min Ye, Wei-Hwa Lee, Liang-Shun Wang, David T.W. Tzeng, Chih-Hsiung Wu, Yi-Shing Shieh, Chi-Ying F. Huang, Yu-Jen Chen, Michael Hsiao, Alexander T.H. Wu, Zhen Yang, Yew-Min Tzeng. A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells. Carcinogenesis 34 (12):2918-2928. (2013)

89. Chia-Hung Liu, Tzu-Chi Chen, Chun-Houh Chen, Cheng-Yan Kao, Chi-Ying F. Huang. Differential network biology reveals a positive correlation between a novel protein-protein interaction and cancer cells migration.Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 6610097:2700-2703. (2013)

90. Ming-Huang Chen, Yi-Hua Jan, Peter Mu-Hsin Chang, Yung-Jen Chuang, Yi-Chen Yeh, Hao-Jan Lei, Michael Hsiao, Shiu-Feng Huang, Chi-Ying F. Huang, Gar-Yang Chau*. Expression of GOLM1 correlates with prognosis in human hepatocellular carcinoma.Annals of Surgical Oncology20:S616-S624. (2013)

91. Ka‐Kit Mak, Alexander T. H. Wu, Wei‐Hwa Lee, Tung‐Cheng Chang, Jeng‐Fong Chiou, Liang‐Shun Wang, Chih‐Hsiung Wu, Chi‐Ying F. Huang, Yi‐Shing Shieh, Tsu‐Yi Chao, Chi‐Tang Ho, Gow‐Chin Yen, Chi‐Tai Yeh.Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit. Molecular Nutrition and Food Research57 (7):1123-1134. (2013)

92. Ming-Ying Lan, Wu-Lung R. Yang, Kuan-Ting Lin, Jin-Ching Lin, Yih-Jyh Shann, Ching-Yin Ho, Chi-Ying F. Huang*. Using computational strategies to predict potential drugs for nasopharyngeal Carcinoma. HEAD & NECK36(10):1398-407 (2014)

93. Kuan-Ting Lin, Yih-JyhShann, Gar-Yang Chau, Chun-Nan Hsu, and Chi-Ying F. Huang*.Identification of latent biomarkers in hepatocellular carcinoma by ultra-deep whole-transcriptome sequencing. Oncogene33:4786-4794 (2014)

94. Ching-Shiun Kea, Hsiao-Sheng Liub, Cheng-Hsin Yena, Guan-Cheng Huang, Hung-Chi Cheng, Chi-Ying F. Huang, Chun-Li Su. Curcumin-induced Aurora-Asuppression not only causes mitotic defect and cell cycle arrest but also alters chemosensitivity to anticancer drugs.Journal of Nutritional Biochemistry25(5): 526–539 (2014).

95. Chien-Hung Huang, Min-You Wu, Peter Mu-Hsin Chang, Chi-Ying Huang, Ka-Lok Ng. In silico identification of potential targets and drugsfor non-small cell lung cancer. IET Systems Biology8(2):56-66 (2014)

96. Ming-Huang Chen,Kun-Chun Chiang, Chi-Tung Cheng, Shih-Chiang Huang, Yeng-Yang Chen, Tsung-Wen Chen, Ta-Sen Yeh, Yi-Yin Jan, Hsi-Ming Wang, Jiang-Jie Weng, Peter Mu-Hsin Chang, Chun-Yu Liu, Chung-Pin Li, Yee Chao, Ming-Han Chen, Chi-Ying F. Huang*, Chun-Nan Yeh*. Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma. Oncotarget5(9):2372-89. (2014)(*corresponding author)

97. Chien-Hung Huang, Peter Mu-Hsin Chang, Yong-Jie Lin, Cheng-Hsu Wang, Chi-Ying F. Huang*, and Ka-Lok Ng*. Drug Repositioning Discovery for Early-and Late-Stage Non-Small-Cell Lung Cancer. BioMed Research International 2014:1-13 (2014)(*corresponding author)

98. Pei-Jung Wu, Wu-Hsiung Wu, Tzu-Chi Chen, Kuan-Ting Lin, Jin-Mei Lai, Chi-Ying F. Huang, Feng-Sheng Wang. Reconstruction and analysis of a signal transduction network using HeLa cell protein–protein interaction data. Journal of the Taiwan Institute of Chemical Engineers45(6):2835-2842. (2014)

99. Tzu-Chi Chen, Sheng-An Lee, Kuan-Ting Lin, Chun-Houh Chen,Hsuan-Cheng Huang, Pei-Ying Lee, Yu-Wen Liu, Yu-LunKuo, Ming-Hui Yu, Wilber Huang, Jin-Mei Lai, and Chi-Ying F. Huang*. Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. Journal of Proteome Research13(12):5339-5346 (2014)

100. Do Thi Thao, Chi-Ying Huang, Kuan-Ting Lin, Do Thi Phuong, Nguyen Thi Nga, Nguyen Thi Trang, Nguyen Thi Cuc, Nguyen Xuan Cuong, Nguyen Hoai Nam and Chau Van Minh. Using the Gene Expression Signature of Scutebarbalactone VN Isolated from Scutellaria barbata to elucidateitsAnticancer Activities. Natural Product Communications10(2):353-355(2015)

101. Hong-Jhih Jhuang, Wei-Hsiang Hsu, Kuan-Ting Lin, Shih-Lan Hsu, Feng-Sheng Wang, Chen-Kung Chou, Kuen-Haur Lee, Ann-Ping Tsou, Jin-Mei Lai*, Sheau-Farn Yeh*, Chi-Ying F. Huang*. Gluconeogenesis, lipogenesis, and HBV replication are commonly regulated by PGC-1α-dependent pathway. Oncotarget6(10):7788-803 (2015).(*corresponding author)

102. Wei-Hsiang Hsu, Chia-Chuan Chang,Kai-Wen Huang, Yi-Chen Chen, Shih-Lan Hsu, Ann-Ping Tsou, Jin-Mei Lai, Chi-Ying F. Huang*.Evaluation of the Medicinal HerbGraptopetalum paraguayenseas a Treatment for Liver Cancer.PLOS ONE10(4):e0121298 (2015).

103. Hui-Wen Cheng, Yu-Hsin Liang, Yu-Lun Kuo, Chih-Pin Chuu, Ching-Yu Lin, Meng-Hua Lee, Alexander T. H. Wu, Chi-Tai Yeh, Edmund I-Tsuen Chen, Jacqueline Whang-Peng, Chun-LiSu*, Chi-Ying F. Huang*. Identification of Thioridazine, an anti-psychotic drug, as an anti-glioblastoma and anti-cancer stem cell agent using public gene expression data. Cell Death and Disease6:e1753(2015).(*corresponding author)

104. Yu-Lun Kuo, Chun-Houh Chen, Tsung-Hsien Chuang, Wei-Kai Hua, Wey-Jinq Lin, Wei-Hsiang Hsu, Peter Mu-Hsin Chang, Shih-Lan Hsu, Tse-Hung Huang, Cheng-Yan Kao, Chi-Ying F. Huang*. Gene expression profiling and pathway network analysis predicts a novel anti-tumor function for a botanical-derived drug, PG2. Evidence-Based Complementary and Alternative Medicine2015 (2015).

105. Sheng-Ming Wu, Wan-Li Cheng, Chia-Jung Liao,Hsiang-Cheng Chi, Yang-Hsiang Lin,Yi-Hsin Tseng, Chung-Ying Tsai, Ching-Ying Chen, Syuan-Ling Lin,  Wei-Jan Chen, Yung-Hsin Yeh, Chi-Ying F. Huang, Ming-Huang Chen, Yi-Chen Yehand Kwang-Huei Lin. Negative modulation of the epigenetic regulator, UHRF1, by thyroid hormone receptors suppresses liver cancer cell growth.International Journal of Cancer 137:37-49 (2015)

106. Ming-Huang Chen, Chueh-Chuan Yen, Chi-Tung Cheng, Ren-Chin Wu, Shih-Chiang Huang, Chung-Shan Yu, Yi-Hsiu Chung, Chun-Yu Liu, Peter Mu-Hsin Chang, Yee Chao, Ming-Han Chen, Yu-Fen Chen, Kun-Chun Chiang, Ta-Sen Yeh, Tzu Chi Chen, Chi-Ying F. Huang* and Chun-Nan Yeh*. Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma. Oncotarget6(27):23594-608.(2015)(*corresponding author)

107. Pi-Lin Sung, Yi-Hua Jan, Shih-Chieh Lin, Chao-Cheng Huang, Hao Lin, Kuo-Chang Wen, Kuan-Chong Chao, Chiung-Ru Lai, Peng-Hui Wang, Chi-Mu Chuang, Hua-Hsi Wu, Nae-Fang Twu, Ming-Shyen Yen, Michael Hsiao*, Chi-Ying F. Huang*. Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma. Oncotarget7(4):4036-47 (2016).(*corresponding author)

108. Chien-Hung Huang, Peter Mu-Hsin Chang, Chia-Wei Hsu, Chi-Ying F. Huang and Ka-Lok Ng. Drug repositioning for non-small cell lung cancer by using machine learning algorithms and topological graph theory. BMC Bioinformatics17(1):2 (2016).

109. Kun-Chun Chiang, Chi-Chin Sun, Ming-Huang Chen,Chi-Ying Huang, Jun-Te Hsu, Ta-Sen Yeh, Li-Wei Chen, Sheng-Fong Kuo, Horng-Heng Juang, Masashi Takano, Atsushi Kittaka, Tai C Chen, Chun-Nan Yeh, , Jong-Hwei S. Pang. MART-10, the new brand of 1a,25(OH)2D3 analog, is a potent anti-angiogenic agent in vivo and in vitro. The Journal of Steroid Biochemistry and Molecular Biology155(Pt A):26-34 (2016)

110. Tzu-Chi Chen and Chi-Ying F. Huang*. Use of in situ Proximity Ligation Assays for Systems Analysis of Signaling Pathways. Current Protocols in Cell Biology71:17.18.1-17.18.11 (2016)

111. Shen-Jeu Won, Hsiao-Sheng Liu, Jyun-Ti Chen, Ting-Yu Lin, Chun-Nan Lin, Yi-Ting Chen, Cheng-Hsin Yen, Cheng-Hao Yu, Chi-Ying F. Huang, Yu-Hau Tzeng, hi-Shiuan Wu, Chun-Li Su. A novel natural tautomeric pair of garcinielliptone FC suppressed nuclear factor κB and induced apoptosis in human colorectal cancer cells. Journal of Functional Foods24:568-578 (2016)

112. Tzeng Tsai-Teng, Chen Chin-Chu, Lee Li-Ya, Chen Wan-Ping, Lu Chung-Kuang, Shen Chien-Chang, Huang F. Chi-Ying, Chen Chien-Chih and Young-Ji Shiao. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice. Journal of Biomedical Science23(1):49 (2016)

113. Chien-Hung Huang, Jin-Shuei Ciou, Shun-Tsung Chen, Victor C. Kok, Yi Chung, Jeffrey J. P. Tsai, Nilubon Kurubanjerdjit, Chi-Ying F. Huang*, Ka-Lok Ng*. Identify potential drugs for cardiovascular diseases caused by stress-induced genes in vascular smooth muscle cells. PeerJ 4:e2478(2016)(*corresponding author)

114. Da-Wei Yeh, Li-Rung Huang, Ya-Wen Chen, Chi-Ying F. Huang and Tsung-Hsien Chuang. Interplay between inflammation and stemness in cancer cells: The role of Toll-likereceptor signaling. Journal of Immunology Research2016: ID 4368101 (2016)

115. Shun-Tsung Chen, Chien-Hung Huang, Victor C. Kok, Chi-Ying F. Huang, Jin-Shuei Ciou, Jeffrey J. P. Tsai, Nilubon Kurubanjerdjit, and Ka-Lok Ng. Drug repurposing and therapeutic anti-microRNA predictionsfor inhibition of oxidized low-density lipoprotein-inducedvascular smooth muscle cell-associated diseases. Journal of Bioinformatics and Computational Biology15(1):1650043(1-23) (2017)

116. Chun-Li Su, Chia-Ling Tseng, Chintakunta Ramesh,Hsiao-Sheng Liu, Chi-Ying F. Huang*, Ching-Fa Yao*. Using gene expression database to uncover biology functions of 1,4-disubstituted 1,2,3-triazole analogues synthesized via a copper (I)-catalyzed reaction. European Journal of Medicinal Chemistry132:90-107 (2017) (*corresponding author)

117. Hua-Qing Wu , Mei-Ling Cheng , Jin-Mei Lai , Hsuan-Hui Wu, Meng-Chun Chen, Wen-Huan Liu, Wu-Hsiung Wu, Peter Mu-Hsin Chang, Chi-Ying F. Huang, Ann-Ping Tsou, Ming-Shi Shiao, Feng-Sheng Wang. Flux balance analysis predicts Warburg-like effects of mouse hepatocyte deficient in miR-122a. PLOS Computational Biology13(7): e1005618(2017).

118. Shu-Fang Lin, Jia-Ying Chien, Chi-Ying F. Huang*, Shun-Ping Huang*. Oroxylin A Promotes Retinal Ganglion Cell Survival in a rat optic nerve crush model. PLOS ONE12(6):e0178584(2017).(*corresponding author)

119. Shen-Jeu Won, Cheng-Hsin Yen, Hao-Wen Hsieh, Shao-Wei Chang, Chun-Nan Lin, Chi-Ying F. Huang*, Chun-Li Su*. Using connectivity map to identify natural lignan justicidin A as a NF-kB suppressor. Journal of Functional Foods 34: 68–76 (2017). (*corresponding author)

120. Yu-Feng Hu*, Yao-Ting Chang, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Yen-Hua Huang, Tze-Tze Liu, Che-Hong Chen, Ta-Chuan Tuan, Tze-Fan Chao, Fa-Po Chung, Jo-Nan Liao, Abigail Louise D. Te, Chi-Ying F. Huang*, Shih-Ann Chen. The roles of alcohol dehydrogenase in patients with atrial fibrillation. Pacing and Clinical Electrophysiology40(12):1446-1453 (2017) (*corresponding author)

121. Pi-Lin Sung, Kuo-Chang Wen, Yi-Jen Chen, Ta-ChungChao, Yi-Fang Tsai, Ling-Ming Tseng, Jian-Tai Timothy Qiu, Kuan-Chong Chao, Hua-Hsi Wu, Chi-Mu Chuang, Peng-Hui Wang*, Chi-Ying F. Huang*. The frequency of cancer predisposition gene mutations in hereditary breast and ovarian cancer patients in Taiwan: From BRCA1/2 to multi-gene panels. PLOS ONE12(9):e0185615 (2017) (*corresponding author)

122. Peter Mu-Hsin Chang, Che-Hong Chen, Chi-Chun Yeh, Hsueh-Ju Lu, Tze-Tze Liu, Ming-Huang Chen, Chun-Yu Liu, Alexander T. H. Wu, Muh-Hwa Yang, Shyh-Kuan Tai, Daria Mochly-Rosen, Chi-Ying F. Huang*. Transcriptome analysis and prognosis of ALDH isoforms in human cancer. Scientific Reports8(1):2713 (2018)

123. Wu-Hsiung Wu, Chen-Yu Chien, Yu-Hao Wu, Hsuan-Hui Wu, Jin-Mei Lai, Peter Mu-Hsin Chang, Chi-Ying F. Huang, Feng-Sheng Wang. Inferring oncoenzymes in a genome-scale metabolic network for hepatocytes using bilevel optimization framework.Journal of the Taiwan Institute of Chemical Engineers91:97-104 (2018)

124. Szu-Yuan Wu, Yan-Jiun Huang, Yew-Min Tzeng, Chi-Ying F. Huang, Michael Hsiao, Alexander T.H. Wu, and Tse-Hung Huang. Destruxin B Suppresses Drug-Resistant Colon Tumorigenesis and Stemness Is Associated with theUpregulation of miR-214 and Downregulation of mTOR/β-Catenin Pathway.Cancers (Basel)10(10): 353 (2018)

125. Cheng-Wei Chu, Huey-Jiun Ko, Chia-Hua Chou, Tai-Shan Cheng, Hui-Wen Cheng, Yu-Hsin Liang, Yun-Ling Lai, Chen-Yen Lin, Chihuei Wang, Joon-Khim Loh, Jiin-Tsuey Cheng, Shean-Jaw Chiou, Chun-Li Su, Chi-Ying F. Huang*, and Yi-Ren Hong*. Thioridazine Enhances P62-Mediated Autophagy and Apoptosis Through Wnt/β-Catenin Signaling Pathway in Glioma Cells.International Journal of Molecular Sciences20(3):473 (2019) (*corresponding author)

126. Jing-Ming Chen, Ting-Ting Yang, Tai-Shan Cheng, Ting-Fen Hsiao, Peter Mu-Hsin Chang, Jyh-Yih Leu, Feng-Sheng Wang, Shih-Lan Hsu, Chi-Ying F. Huang, Jin-Mei Lai. Modified Sijunzi decoction can alleviate cisplatin-induced toxicity and prolong the survival time of cachectic mice by recovering muscle atrophy. Journal of Ethnopharmacology233:47-55 (2019)

127. Yen-Bin Hsu, Chi-Ying F. Huang, Kuan-Ting Lin, Yu-Lun Kuo, Ming-Chin Lan and Ming-Ying Lan. Podoplanin, a Potential Therapeutic Target for Nasopharyngeal Carcinoma. BioMed Research International 2019:7457013(2019)

128. Wei-Hsiang Hsu, Se-Chun Liao, Yau-Jan Chyan, Kai-Wen Huang, Shih-LanHsu, Yi-Chen Chen, Ma-Li Siu, Chia-Chuan Chang, Yuh-Shan Chung, Chi-Ying F. Huang*. Graptopetalum paraguayense Inhibits Liver Fibrosis by Blocking TGF-βSignaling In Vivo and In Vitro. International Journal of Molecular Sciences20(10):2592 (2019)

129. Yen-Bin Hsu, Ming-Chin Lan, Yu-Lun Kuo, Chi-Ying F. Huang*, Ming-Ying Lan*. A preclinical evaluation of thiostrepton, a natural antibiotic, in nasopharyngeal carcinoma. Investigational New Drugs38(2):264-273(2019)(*corresponding author)

130. Se-Chun Liao, Hsiu-Wen Hsu, Kun-Lin Chuang, Zi-Yi Huang, Kuan-Ting Lin, Wei-Hsiang Hsu, Kai-Hsun Chang, Chi-Yin F. Huang*, Chun-Li Su*. Using the Pleiotropic Characteristics of Curcumin to Validate thePotential Application of a Novel Gene Screening Platform. Nutrients11(6):1397 (2019) (*corresponding author)

131. Jade H.-M. Hsu, Peter M.-H. Chang, Tai-Shan Cheng, Yu-Lun Kuo, Alexander T.-H. Wu, Thu-Ha Tran, Yun-Hsuan Yang, Jing-Ming Chen, Yu-Chen Tsai, Yeh-Shiu Chu, Tse-Hung Huang*, Chi-Ying F. Huang*, and Jin-Mei Lai*.Identification of Withaferin A as a Potential Candidate for Anti-Cancer Therapy in Non-Small Cell Lung Cancer. Cancers11(7):1003 (2019) (*corresponding author)

132. Yan-Jiun Huang, Vijesh Kumar Yadav, Prateeti Srivastava, Alexander TH Wu, Thanh-Tuan Huynh, Po-Li Wei, Chi-Ying F. Huang, Tse-Hung Huang. Antrodia cinnamomea enhances chemo-sensitivity of 5-FU and suppresses colon tumorigenesis and cancer stemness via up-regulation of tumor suppressor miR-142-3p. Biomolecules9(8):306 (2019)

133. Chi-Shiuan Wu, Shan-Ying Wu, Hsin-Chih Chen, Chien-An Chu, Han-Hsuan Tang, Hsiao-Sheng Liu, Yi-Ren Hong, Chi-Ying F. Huang*, Guan-Cheng Huang*, Chun-Li Su*. Curcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib. The Journal of Nutritional Biochemistry74:108227 (2019) (*corresponding author)

134. Hsueh-Ju Lu, Chih-Cheng Hsieh, Chi-Chun Yeh, Yi-Chen Yeh, Chun-Chi Wu, Feng-Sheng Wang, Jin-Mei Lai, Muh-Hwa Yang, Cheng-Hsu Wang, Chi-Ying F. Huang*, and Peter Mu-Hsin*. Clinical, pathophysiologic, and genomic analysis of the outcomes of primary head and neck malignancyafter pulmonary metastasectomy. Scientific Reports9:12913 (2019) (*corresponding author)

135. Huey-Jiun Ko, Shean-Jaw Chiou, Yu-Hui Wong, Yin-Hsuan Wang, Yun-Ling Lai, Chia-Hua Chou, Chihuei Wang, Joon-Khim Loh, Ann-Shung Lieu, Jiin-Tsuey Cheng, Yu-Te Lin, Pei-Jung Lu, Ming-Ji Fann, Chi-Ying Huang*, Yi-Ren Hong*. GSKIP-mediated anchoring increases phosphorylation of Tau by PKA but not by GSK3beta via cAMP/PKA/GSKIP/GSK/Tau axis signaling in cerebrospinal fluid and iPS cells in Alzheimer disease.Journal of Clinical Medicine8(10):1751 (2019) (*corresponding author)

136. Tse-Hung Huang, Alexander T. H. Wu, Tai-Shan Cheng, Kuan-Ting Lin, Chia-Jou Lai, Hao-Wen Hsieh, Peter Mu-Hsin Chang, Cheng-Wen Wu, Chi-Ying F. Huang*, Kuan-Yu Chen*.In silico Identification of Thiostrepton asan Inhibitor of Cancer Stem Cell Growth and an Enhancer for Chemotherapy in Non-small Cell Lung Cancer. Journal of Cellular and Molecular Medicine23(12):8184-8195 (2019)(Epub)(*corresponding author)

137. Se-Chun Liao, Wei-Hsiang Hsu, Zi-Yi Huang,Kun-Lin Chuang, Kuan-Ting Lin, Chia-Ling Tseng, Tung-Hu Tsai, Anh-Hoang Dao, Chun-Li Su*, and Chi-Ying F. Huang*.Bioactivity Evaluation of a Novel Formulated Curcumin. Nutrients11(12):2982 (2019) (*corresponding author)

138. Pei-ChunWu, Ming-Ji Fann, Tu ThanhTran, Shu-CianChen, Tania Devina, Irene Han-Juo Cheng, Cheng-Chang Lien, Lung-Sen Kao, Shuu-JiunWang, Jong-Ling Fuh, Tsai-TengTzeng, Chi-Ying Huang, Young-Ji Shiao* and Yu-HuiWong*. Assessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer’s disease using patient iPSC-derived neurons.ScientificReport9(1):19301 (2019)

139. Wu-Hsiung Wu, Fan-Yu Li, Yi-Chen Shu, Jin-Mei Lai, Peter Mu-Hsin Chang, Chi-Ying F. Huang and Feng-Sheng Wang. Oncogene inference optimization using constraint-based modelling incorporated with protein expression in normal and tumour tissues. Royal Society Open Science7(3):191241 (2020)

140. Yu-Chen Chuang, Jen-Chih Tseng, Li-Rung Huang, Chun-Ming Huang, Chi-Ying F.Huang, Tsung-Hsien Chuang. Adjuvant Effect of Toll-like Receptor 9 Activation on Cancer Immunotherapy Using Checkpoint Blockade. Frontiers in Immunology, section Cancer Immunity and Immunotherapy 11:1075 (2020)

141. Kuo-Chang Wen, Pi-Lin Sung, Alexander T.H. Wu, Ping-Chieh Chou, Jun-Hung Lin, Chi-Ying F. Huang, Sai-Ching J. Yeung, Mong-Hong Lee. Neoadjuvant Metformin Added to Conventional Chemotherapy Synergizes Anti-Proliferative Effects in Ovarian Cancer. Journal of Ovarian Research (2020) (accepted)