Hsuan-Cheng Huang

Personal Profile

Hsuan-Cheng Huang
Professor, Institute of Biomedical Informatics
PhD of Physics, National Taiwan University, Taiwan
f Field of Interest: Network Biology, Systems Biology, Bioinformatics
Office: R305, 3F, SoRen Building
Phone: 886-2-28267357
Email: hsuancheng@nycu.edu.tw

Research Interests

  • 網路生物學 (Networks Biology)
  • 系統生物學 (Systems Biology)
  • 生物資訊學 (Bioinformatics)


  • Huang TC, Chang HY, Chen CY, Wu PY, Lee H, Liao YF, Hsu WM*, Huang HC*, Juan HF*, “Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR.” FEBS Lett, in press.
  • Lee CH, Huang HC*, Juan HF*, “Reviewing ligand-based rational drug design: the search for an ATP synthase inhibitor.” Int J Mol Sci, 12:5304-18 (2011).
  • Tseng CW, Lin CC, Chen CN*, Huang HC*, Juan HF*, “Integrative network analysis reveals active microRNAs and their functions in gastric cancer.” BMC Syst Biol, 5:99 (2011).
  • Tseng CW, Yang JC, Chen CN*, Huang HC, Chuang KN, Lin CC, Lai HS, Lee PH, Chang KJ, Juan HF*, “Identification of 14-3-3β in human gastric cancer cells and its potency as a diagnostic and prognostic biomarker.” Proteomics, 11:2423-39 (2011).
  • Chen CY, Chen ST, Fuh CS, Juan HF*, Huang HC*, “Coregulation of transcription factors and microRNAs in human transcriptional regulatory network.” BMC Bioinformatics, 12 (Suppl 1), S41 (2011).
  • Lin CC, Hsiang JT, Wu CY, Oyang YJ, Juan HF*, Huang HC*, “Dynamic functional modules in co-expressed protein interaction networks of dilated cardiomyopathy.” BMC Syst Biol, 4, 138 (2010).
  • Wu TH, Chang IYF, Huang HC*, Ng WV*, “Modularity of Escherichia coli sRNA regulation revealed by sRNA-targets and protein network analysis.” BMC Bioinformatics, 11 (Suppl 7), S11 (2010).
  • Hsu JW, Huang HC, Lee TY, Chen ST, Wong CH, Juan HF, “Ganoderma lucidum polysaccharides induce macrophage-like differentiation in human leukemia THP-1 cells via caspase and p53 activation.” Evid based Complement Altern Med, 2011:358717 (2011).
  • Hwang YC, Lin CC, Chang JY, Mori H, Juan HF*, Huang HC*, “Predicting essential genes based on network and sequence analysis.” Mol BioSyst, 5, 1672–1678 (2009).
  • Lin CC, Juan HF, Hsiang JT, Hwang YC, Mori H*, Huang HC*, “Essential core of protein-protein interaction network in Escherichia coli.” J Proteome Res, 8, 1925–1931 (2009).
  • Hsu CW, Juan HF*, Huang HC*, “Characterization of microRNA-regulated protein-protein interaction network.” Proteomics, 8, 1975-9 (2008).
  • Hsu CW, Juan HF*, Huang HC*, “Characterization of microRNA-regulated protein-protein interaction network” Proteomics, in press.
  • Fang YC, Huang HC*, Juan HF*, “MeInfoText: associated gene methylation and cancer information from text mining” BMC Bioinformatics 9, 22 (2008).
  • Cheng KC†, Huang HC†, Chen JH, Hsu JW, Cheng HC, Ou CH, Yang WB, Chen ST, Wong CH, Juan HF*. “Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction.” BMC Genomics 8, 411 (2007). [Highly accessed]
  • Huang TC, Huang HC, Chang CC, Chang HY, Ou CH, Hsu CH, Chen ST, Juan HF*. “An apoptosis-related gene network induced by novel compound-cRGD in human breast cancer cells.” FEBS Lett 581, 3517-22 (2007).
  • Leu JH, Chang CC, Wu JL, Hsu CW, Hirono I, Aoki T, Juan HF, Lo CF, Kou GH*, Huang HC*. “Comparative analysis of differentially expressed genes in normal and white spot syndrome virus infected Penaeus monodon.” BMC Genomics 8, 120 (2007). [Highly accessed]
  • Tseng HW, Juan HF, Huang HC, Lin JY, Sinchaikul S, Lai TC, Chen CF, Chen ST, Wang GJ. “Lipopolysaccharide-stimulated responses in rat aortic endothelial cells by a systems biology approach.” Proteomics 6, 5915-28 (2006).
  • Chen YR, Juan HF, Huang HC, Huang HH, Lee YJ, Liao MY, Tseng CW, Lin LL, Chen JY, Wang MJ, Chen JH, Chen YJ. “Quantitative proteomic and genomic profiling reveals metastasis-related protein expression patterns in gastric cancer cells.” J Proteome Res 5, 2727-42 (2006).
  • Lee TY, Horng JT, Juan HF, Huang HD, Wu LC, Tsai MF, Huang HC. “An agent-based system to discover protein-protein interactions, identify protein complexes and proteins with multiple peptide mass fingerprints.” J Comput Chem 27, 1020-32 (2006).
  • Juan, H.-F., Wang, I-H., Huang, T.-C., Li, J.-J., Chen, S.-T., Huang, H.-C.*, “Proteomics analysis of a novel compound – cyclic RGD in breast carcinoma cell line MCF-7”, Proteomics, in press. [SCI, 5.483]
  • Lee, T.-Y., Horng, J.-T., Juan, H.-F., Huang, H.-D., Wu, L.-C., Lin, F.-M., Huang, H.-C., “An agent-based system to discover protein-protein interactions, identify protein complexes and proteins with multiple peptide mass fingerprints”, Journal of Computational Chemistry, in press. [SCI, 3.168]
  • Juan, H.-F., Chang, S.-C., Huang, H.-C., Chen, S.-T., “A New Application of Microwave Technology to Proteomics”, Proteomics 5, 840-842 (2005). [SCI, 5.483]
  • C.C. Wu, H.-C. Huang*, H.F. Juan, S.T. Chen, “GeneNetwork: an interactive interface for reconstructing genetic network based on microarray data”, Bioinformatics 20, 3691-3693 (2004).[SCI, 5.742]
  • C.Y. Wu, J.T. Jan, S.H. Ma, C.J. Kuo, H.F. Juan, Y.S.E. Cheng, H.H. Hsu, H.C. Huang, D. Wu, A. Brik, F.S. Liang, R.S. Liu, J.M. Fang, S.T. Chen, P.H. Liang, C.H. Wong, “Small molecules targeting severe acute respiratory syndrome human coronavirus”, Proc. Natl. Acad. Sci. USA 101, 10012-10017 (2004) [SCI, 10.452]
  • D.T.H. Chang, C.Y. Chen, W.C. Chung, Y.J. Oyang, H.F. Juan, H.-C. Huang, “ProteMiner-SSM: A Web Server for Efficient Analysis of Similar Protein Tertiary Substructures”, Nucleic Acids Res. 32, W76-82 (2004). [SCI, 7.260]
  • P. Chang, et al. (Belle Collaboration), “Measurements of branching fractions and CP asymmetries in B → eta h decays”, Phys. Rev. D 71, 091106 (2005). [SCI, 5.156]
  • H.-C. Huang*, et al. (Belle Collaboration), “Evidence for B→phi phi K”, Phys. Rev. Lett. 91, 241802 (2003). [first & corresponding author; SCI, 7.218, top of Physics]
  • M.-Z. Wang, et al. (Belle Collaboration), “Observation of B0 → p Lambda(pi)(-)”, Phys. Rev. Lett. 90, 201802 (2003). [SCI, 7.218]
  • R.-S. Lu, …, H.-C. Huang*, et al. (Belle Collaboration), “Observation of B→omega K Decay”, Phys. Rev. Lett. 89, 191801 (2002). [corresponding author; SCI, 7.218]
  • K. Abe, et al. (Belle Collaboration), “Observation of B→p pbar K”, Phys. Rev. Lett. 88, 181803 (2002). [Equal contribution to the corresponding author; SCI, 7.218]
  • K. Abe, et al. (Belle Collaboration), “Observation of the Color-Suppressed Decay B→D0 pi0”, Phys. Rev. Lett. 88, 052002 (2002). [Equal contribution to the corresponding author; SCI, 7.218]
  • K. Abe, et al., (Belle Collaboration), “Measurement of the branching fraction for B→η’K and search for B→η’π+”, Phys. Lett. B517, 309 (2001). [SCI, 4.619]
  • M.Z. Wang, H.C. Huang, et al. “Beam test of the BELLE extreme forward calorimeter at KEK”, Nucl. Instr. and Meth. A455, 319 (2000) [SCI, 1.166, Nuclear Science & Technology: 4/33]